ArticleAnalytical chemistry2009
Ultrafast differential ion mobility spectrometry at extreme electric fields in multichannel microchips.
Article in Analytical chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- The detection of patients at risk of gastrointestinal toxicity during pelvic radiotherapy by electronic nose and FAIMS: a pilot study.Sensors (Basel, Switzerland) · 2012Trial
- Determination of Collisional Cross Section Using Microscale High-Field Asymmetric Waveform ion Mobility Spectroscopy-Mass Spectrometry (FAIMS-MS).Rapid communications in mass spectrometry : RCM · 2025Article
- Oxygen enhanced plasma discharge and its application as carrier gas for high-field asymmetric ion mobility spectroscopy.Analytical and bioanalytical chemistry · 2025Article
- Engineering synthetic breath biomarkers for respiratory disease.Nature nanotechnology · 2020Article
- Recommendations for reporting ion mobility Mass Spectrometry measurements.Mass spectrometry reviews · 2019Review
- An improved machine learning pipeline for urinary volatiles disease detection: Diagnosing diabetes.PloS one · 2018Article
- Maximizing Ion Transmission in Differential Mobility Spectrometry.Journal of the American Society for Mass Spectrometry · 2017Article
- Increased Ion Transmission for Differential Ion Mobility Combined with Mass Spectrometry by Implementation of a Flared Inlet Capillary.Journal of the American Society for Mass Spectrometry · 2017Article
- Analysis of Supramolecular Complexes of 3-Methylxanthine with Field Asymmetric Waveform Ion Mobility Spectrometry Combined with Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2016Article
- Rapid, accurate, and on-site detection of C. difficile in stool samples.The American journal of gastroenterology · 2015Article
- Review on ion mobility spectrometry. Part 1: current instrumentation.The Analyst · 2015Review
- Ion mobility-mass spectrometry: time-dispersive instrumentation.Analytical chemistry · 2015Review
- Differential ion mobility separations in up to 100% helium using microchips.Journal of the American Society for Mass Spectrometry · 2014Article
- Resolution enhancement of field asymmetric waveform ion mobility spectrometry (FAIMS) by ion focusing.Chemistry Central journal · 2013Article
- High-field asymmetric waveform ion mobility spectrometry for mass spectrometry-based proteomics.Expert review of proteomics · 2012Review
- Protein analyses using differential ion mobility microchips with mass spectrometry.Analytical chemistry · 2012Article
- The Highs and Lows of FAIMS: Predictions and Future Trends for High Field Asymmetric Waveform Ion Mobility Spectrometry.Journal of nanomedicine & nanotechnology · 2012Article
- Nanospray FAIMS fractionation provides significant increases in proteome coverage of unfractionated complex protein digests.Molecular & cellular proteomics : MCP · 2012Article
- Accelerated high-resolution differential ion mobility separations using hydrogen.Analytical chemistry · 2011Article
- Size, weight and position: ion mobility spectrometry and imaging MS combined.Analytical and bioanalytical chemistry · 2011Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The maximum electric field intensity (E) in field asymmetric waveform ion mobility spectrometry (FAIMS) analyses was doubled to E > 60 kV/cm. In earlier devices with >0.5 mm gaps, such strong fields cause electrical breakdown for nearly all gases at ambient pressure. As the Paschen curves are sublinear, thinner gaps permit higher E: here, we established 61 kV/cm in N(2) using microchips with 35 microm gaps. As FAIMS efficiency is exceptionally sensitive to E, such values can in theory accelerate analyses at equal resolution by over an order of magnitude. Here we demonstrate FAIMS filtering in approximately 20 micros or approximately 1% of the previously needed time, with a resolving power of about half that for "macroscopic" units but sufficing for many applications. Microscopic gaps enable concurrent ion processing in multiple (here, 47) channels, which greatly relaxes the charge capacity constraints of planar FAIMS designs. These chips were integrated with a beta-radiation ion source and charge detector. The separation performance is in line with first-principles modeling that accounts for high-field and anisotropic ion diffusion. By extending FAIMS operation into the previously inaccessible field range, the present instrument advances the capabilities for research into ion transport and expands options for separation of hard-to-resolve species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.