ArticleGenetic epidemiology2010
Assessment of SNP streak statistics using gene drop simulation with linkage disequilibrium.
Article in Genetic epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Obelisc: an identical-by-descent mapping tool based on SNP streak.Bioinformatics (Oxford, England) · 2021Article
- Family Study Designs Informed by Tumor Heterogeneity and Multi-Cancer Pleiotropies: The Power of the Utah Population Database.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Article
- Modelling and visualizing fine-scale linkage disequilibrium structure.BMC bioinformatics · 2013Article
- CrypticIBDcheck: an R package for checking cryptic relatedness in nominally unrelated individuals.Source code for biology and medicine · 2013Article
- Employing MCMC under the PPL framework to analyze sequence data in large pedigrees.Frontiers in genetics · 2013Article
- Linkage analysis of extended high-risk pedigrees replicates a cutaneous malignant melanoma predisposition locus on chromosome 9q21.The Journal of investigative dermatology · 2013Article
- Pairwise shared genomic segment analysis in three Utah high-risk breast cancer pedigrees.BMC genomics · 2012Article
- Obtaining accurate p values from a dense SNP linkage scan.Human heredity · 2012Article
- Pairwise shared genomic segment analysis in high-risk pedigrees: application to Genetic Analysis Workshop 17 exome-sequencing SNP data.BMC proceedings · 2011Article
- A method for detecting IBD regions simultaneously in multiple individuals--with applications to disease genetics.Genome research · 2011Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
We describe methods and programs for simulating the genotypes of individuals in a pedigree at large numbers of linked loci when the alleles of the founders are under linkage disequilibrium. Both simulation and estimation of linkage disequilibrium models are shown to be feasible on a genome wide scale. The methods are applied to evaluate the statistical significance of streaks of loci at which sets of related individuals share a common allele. The effects of properly allowing for linkage disequilibrium are shown to be important as they explain many of the large observations. This is illustrated by reanalysis of a previously reported linkage of prostate cancer to chromosome 1p23.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.