ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2009
Immunohistochemical expression of osteopontin in gastric cancer.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Prognostic significance of osteopontin expression in gastric cancer: a meta-analysis.Oncotarget · 2016Pooled it
- Osteopontin, E-cadherin, and β-catenin expression as prognostic biomarkers in patients with radically resected gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2016Trial
- Research progress on the correlation between OPN and immune escape of gastric cancer.Clinical and experimental medicine · 2026Review
- Osteopontin promotes gastric cancer progressionWorld journal of gastrointestinal oncology · 2023Article
- Article
- Integrated bioinformatics analysis of key genes involved in progress of colon cancer.Molecular genetics & genomic medicine · 2019Article
- Identification of molecular biomarkers for the diagnosis of gastric cancer and lymph-node metastasis.Gastroenterology report · 2019Article
- Circulating Levels of Osteopontin Predict Patients' Outcome after Resection of Colorectal Liver Metastases.Journal of clinical medicine · 2018Article
- Three-dimensional combined biomarkers assay could improve diagnostic accuracy for gastric cancer.Scientific reports · 2017Article
- Human osteopontin: Potential clinical applications in cancer (Review).International journal of molecular medicine · 2017Review
- Gene expression profiling in bladder cancer identifies potential therapeutic targets.International journal of oncology · 2017Article
- Osteopontin regulates proliferation, apoptosis, and migration of murine claudin-low mammary tumor cells.BMC cancer · 2016Article
- The significance of the co-existence of osteopontin and tumor-associated macrophages in gastric cancer progression.BMC cancer · 2015Article
- Correlation between calcification and bone sialoprotein and osteopontin in papillary thyroid carcinoma.International journal of clinical and experimental pathology · 2015Article
- Genetic association of osteopontin (OPN) and its receptor CD44 genes with susceptibility to Chinese gastric cancer patients.Journal of cancer research and clinical oncology · 2014Article
- Serum OPN expression for identification of gastric cancer and atrophic gastritis and its influencing factors.PloS one · 2014Article
- Platelet-derived growth factor-A and vascular endothelial growth factor-C contribute to the development of pulmonary tumor thrombotic microangiopathy in gastric cancer.Virchows Archiv : an international journal of pathology · 2013Article
- Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers.World journal of gastroenterology · 2012Review
- Pre- and post-translational regulation of osteopontin in cancer.Journal of cell communication and signaling · 2011Article
- Gene Expression Profiling of Gastric Cancer.Journal of proteomics & bioinformatics · 2011Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsOsteopontin (OPN) is significantly overexpressed in a variety of malignancies. However, little is known concerning the significance of OPN expression in human cancers. Thus, the aim of this study was to determine the relationship between the degree of OPN expression, the proliferative activity of cancer cells, and the clinicopathological findings for surgically resected gastric cancer. METHODOLOGY: We evaluated the immunohistochemical expression of OPN in 85 specimens of cancer. Additionally, we investigated a cancer cell proliferative index using an anti-MIB-1 antibody and terminal deoxynucleotidyl transferase-mediated dUTP biotin nick end labeling staining. Levels of OPN expression in gastric cancers were classified into three groups. To compare the relationship between OPN expression and clinicopathological findings, the features of cancer lesions were classified using the TNM Classification of Malignant Tumors, 6th Edition.
resultsImmunohistochemical examination of OPN expression in gastric cancer revealed diffuse granular staining in the cytoplasm. High OPN expression was observed in 37 of 85 carcinomas. Strong OPN expression was significantly associated with a low apoptotic index, a high proliferative index, depth of invasion, lymphatic invasion, and venous invasion. Pathologically, intestinal type carcinoma showed strong expression of OPN.
conclusionsThese data suggested that OPN may play an important role in the invasiveness and the progressive nature of gastric cancer.
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