Evidence map›Paper›PMID 19582408›Full record

ReviewResults and problems in cell differentiation2009

Axon regeneration in the peripheral and central nervous systems.

Eric A Huebner, Stephen M Strittmatter

Open access · greenAbstract readReview
In one paragraph

Review in Results and problems in cell differentiation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 193 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
193citing papers in PubMed, 1 pooled it
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

193 citing papers in PubMed, 1 synthesis or guideline pooled it, 406 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Combinatorial expression of glial transcription factors induces Schwann cell-specific gene expression in mouse embryonic fibroblasts.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. The conserved fibroblast growth factor receptor-based signaling is required for dendrite regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Regional Molecular Diversity in Chronic Spinal Cord Injury.Cellular and molecular neurobiology · 2026
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. IGFBP2-Ceramide Pathway Mediates Divergent Myelin Breakdown in the PNS and CNS Following Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Review

133 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Eric A HuebnerProgram in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, USA.
Stephen M Strittmatter
Yale University · US

Funding

MOLECULAR DETERMINANTS OF AXONAL REGENERATIONR01NS039962 · NINDS · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2000 to 2010
$3.9M
Nogo Receptor in Axonal RegenerationR01NS042304 · NINDS · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2001 to 2010
$3.3M
Axonal Growth Cone Signal TransductionR37NS033020 · NINDS · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2005 to 2011
$2.9M
Nogo Receptor Antagonist for Ischemic Stroke RecoveryR01NS056485 · NINDS · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2006 to 2010
$1.4M
NINDS NIH HHS R01 NS039962NINDS NIH HHS R01 NS042304NINDS NIH HHS R01 NS056485NINDS NIH HHS R37 NS033020
6 · The paper itself

Abstract

Axon regeneration in the mature mammalian central nervous system (CNS) is extremely limited after injury. Consequently, functional deficits persist after spinal cord injury (SCI), traumatic brain injury, stroke, and related conditions that involve axonal disconnection. This situation differs from that in the mammalian peripheral nervous system (PNS), where long-distance axon regeneration and substantial functional recovery can occur in the adult. Both extracellular molecules and the intrinsic growth capacity of the neuron influence regenerative success. This chapter discusses determinants of axon regeneration in the PNS and CNS.

Indexed as

Nerve RegenerationAnimalsAxonsCentral Nervous SystemChondroitin Sulfate ProteoglycansCornified Envelope Proline-Rich ProteinsHumansPeripheral Nervous SystemSignal TransductionChondroitin Sulfate ProteoglycansCornified Envelope Proline-Rich ProteinsSPRR1A protein, human

Identifiers

PMID19582408
PMCPMC2846285
OpenAlexW82040228

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.