ArticleInternational urogynecology journal and pelvic floor dysfunction2009
Caldesmon expression is decreased in women with anterior vaginal wall prolapse: a pilot study.
Article in International urogynecology journal and pelvic floor dysfunction, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- A Non-Invasive Determination of LOXL1 and Fibulin-5 Levels in the Vaginal Secretions of Women with and Without Pelvic Organ Prolapse.Journal of medical research and surgery · 2021Article
- The impact of prolapse mesh on vaginal smooth muscle structure and function.BJOG : an international journal of obstetrics and gynaecology · 2016Article
- Effect of estrogen on molecular and functional characteristics of the rodent vaginal muscularis.The journal of sexual medicine · 2013Article
- Regional differences in rat vaginal smooth muscle contractility and morphology.Reproductive sciences (Thousand Oaks, Calif.) · 2013Article
- TGF-beta 1 is a potential regulator of vaginal tropoelastin production.International urogynecology journal · 2012Article
- Contractile response of human anterior vaginal muscularis in women with and without pelvic organ prolapse.Reproductive sciences (Thousand Oaks, Calif.) · 2011Article
- The calpain system as a potential target for pelvic muscle reinforcement.Central European journal of urology · 2011Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisThe purpose of this study is to compare vaginal caldesmon expression in women with and without anterior vaginal wall prolapse.
methodsVaginal tissues were sampled in women with (n = 11) or without (n = 11) vaginal wall prolapse. Caldesmon messenger RNA (mRNA) expression was assessed by quantitative real-time polymerase chain reaction. Immunohistochemistry and digital image analysis were used to determine caldesmon protein expression in the histologic sections.
resultsThere were no significant differences in demographic data between the two groups. Caldesmon mRNA expression was significantly decreased in the vaginal tissue from women with anterior vaginal wall prolapse compared to women without prolapse [(caldesmon mean +/- SD mRNA expression in relative units) 0.03 +/- 0.03 vs 0.17 +/- 0.17, P = 0.02]. The fractional area of nonvascular caldesmon staining in the vagina of women with anterior vaginal wall prolapse was significantly decreased compared to women without prolapse [mean +/- SD (0.09 +/- 0.04 vs 0.16 +/- 0.09, P = 0.03)].
conclusionsVaginal caldesmon expression is significantly decreased in women with anterior vaginal wall prolapse compared to normal subjects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.