ArticleBrazilian journal of otorhinolaryngology
Ototoxicity and otoprotection in the inner ear of guinea pigs using gentamicin and amikacin: ultrastructural and functional aspects.
Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 15 citations in OpenAlex.
- Autophagic flux, a possible mechanism for delayed gentamicin-induced ototoxicity.Scientific reports · 2017Article
- An Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats.Clinical and experimental otorhinolaryngology · 2015Article
- Risk factors and prevalence of newborn hearing loss in a private health care system of Porto Velho, Northern Brazil.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2013Article
- Evaluation of the protective effect of Beta glucan on amikacin ototoxicity using distortion product otoacoustic emission measurements in rats.Clinical and experimental otorhinolaryngology · 2013Article
- Otoprotection in guinea pigs exposed to pesticides and ginkgo biloba.Brazilian journal of otorhinolaryngology · 2012Article
- Interaction of gentamicin with phosphatidylserine/phosphatidylcholine mixtures in adsorption monolayers and thin liquid films: morphology and thermodynamic properties.European biophysics journal : EBJ · 2010Article
- The effects of hyperbaric oxygen therapy upon ototoxic injuries produced by amikacin in guinea pigs.Brazilian journal of otorhinolaryngologyArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledOtotoxicity is still a challenge to medicine. The discovery of self-protecting endogenous mechanisms of the outer hair cells associated with their functional and ultra-structural assessment methods has opened new horizons in the understanding and controlling of these mechanisms.
aimthis paper aimed at establishing whether or not underdoses of gentamicin could protect the inner ear against the harmful effects of amikacin, based on these protection mechanisms and determine if the otoacoustic emission amplitudes could be associated with the level of hair cell integrity. MATERIALS AND
methodsExperimental study. We used 31 guinea pigs. They were injected with saline solution, gentamicin and amikacin, alone and in combinations -intramuscular injections - during 12, 30 and 42 days. The otoacoustic emissions were recorded in the beginning and at the end of the experiment, comparing it with the cochlear integrity study carried out by electron microscopy.
resultsgentamicin underdoses did not protect the inner ear against amikacin toxicity; the reduction in otoacoustic emissions was strongly associated with an increase in hair cell lesions.
conclusionthese findings help understand inner ear otoprotection and ototoxicity. Establishing the correlation between the emissions amplitude an cell integrity plays an important role in the follow up of hair cell damage, with possible monitoring of ototoxicity caused by drugs in humans.
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