ReviewThe pharmacogenomics journal2009
Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review.
Review in The pharmacogenomics journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Investigation of 7-dehydrocholesterol reductase pathway to elucidate off-target prenatal effects of pharmaceuticals: a systematic review.The pharmacogenomics journal · 2016Pooled it
- 1-C Metabolism-Serine, Glycine, Folates-In Acute Myeloid Leukemia.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Omics-based analyses revealed metabolic responses ofBiotechnology for biofuels · 2019Article
- The effects of vitamin BIranian journal of basic medical sciences · 2018Article
- Association of Nicotinamide-N-Methyltransferase Gene rs694539 Variant with Epilepsy.Molecular neurobiology · 2016Article
- Folate-related polymorphisms in gastrointestinal stromal tumours: susceptibility and correlation with tumour characteristics and clinical outcome.European journal of human genetics : EJHG · 2015Article
- Geographical and ethnic distribution of single nucleotide polymorphisms within genes of the folate/homocysteine pathway metabolism.Genes & nutrition · 2014Article
- Discovery and functional assessment of gene variants in the vascular endothelial growth factor pathway.Human mutation · 2014Article
- Neuropathological and neuroprotective features of vitamin B12 on the dorsal spinal ganglion of rats after the experimental crush of sciatic nerve: an experimental study.Diagnostic pathology · 2013Article
- One-carbon metabolism factors and leukocyte telomere length.The American journal of clinical nutrition · 2013Article
- Molecular mechanisms underlying the potentially adverse effects of folate.Clinical chemistry and laboratory medicine · 2013Review
- One-carbon metabolism factors and endometrial cancer risk.British journal of cancer · 2013Article
- A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2-wk trial.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Cancer control and prevention by nutrition and epigenetic approaches.Antioxidants & redox signaling · 2012Review
- (1)H NMR-based metabolomic analysis for identifying serum biomarkers to evaluate methotrexate treatment in patients with early rheumatoid arthritis.Experimental and therapeutic medicine · 2012Article
- Potential value of nutrigenomics in Crohn's disease.Nature reviews. Gastroenterology & hepatology · 2012Review
- Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition.Genome research · 2012Article
- Epistatic interactions between loci of one-carbon metabolism modulate susceptibility to breast cancer.Molecular biology reports · 2011Article
- Profiling single nucleotide polymorphisms (SNPs) across intracellular folate metabolic pathway in healthy Indians.The Indian journal of medical research · 2011Article
- Mathematical modeling of folate metabolism.Wiley interdisciplinary reviews. Systems biology and medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic polymorphisms in the one-carbon folate pathway have been widely studied in association with a number of conditions. Most of the research has focused on the 677C>T polymorphism in the coding region of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. However, there are a total of 25 genes in this pathway coding for enzymes, transporters and receptors, which can be investigated using 267 tagging single nucleotide polymorphisms (SNPs); using SNP database (dbSNP), 38 non-synonymous SNPs with a minor allele frequency of >5% are present in these genes. Most of these variants have not been investigated in relation to disease or drug response phenotypes. In addition, their functional consequences are largely unknown. Prediction of the functional effect using six publicly available programs (PolyPhen, SIFT BLink, PMut, SNPs3D, I-Mutant2.0 and LS-SNP) was limited to functionally well-characterized SNPs such as MTHFR c.677C>T and c.1298A>C ranking low. Epigenetic modifications may also be important with some of these genes. In summary, to date, investigation of the one-carbon folate pathway genes has been limited. Future studies should aim for a more comprehensive assessment of this pathway, while further research is also required in determining the functional effects of these genetic variants.
Indexed as
Identifiers
19581920What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.