ArticleJournal of immunology (Baltimore, Md. : 1950)2009
Absence of IFN-beta impairs antigen presentation capacity of splenic dendritic cells via down-regulation of heat shock protein 70.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer's patch.Immunity · 2023Article
- IFNAR1 Deficiency Impairs Immunostimulatory Properties of Neutrophils in Tumor-Draining Lymph Nodes.Frontiers in immunology · 2022Article
- Temporal analysis of type 1 interferon activation in tumor cells following external beam radiotherapy or targeted radionuclide therapy.Theranostics · 2021Article
- Genetic and non-genetic factors associated with the phenotype of exceptional longevity & normal cognition.Scientific reports · 2020Article
- Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer.Nature communications · 2017Article
- Type I Interferons and Natural Killer Cell Regulation in Cancer.Frontiers in immunology · 2017Review
- IFNAR signaling directly modulates T lymphocyte activity, resulting in milder experimental autoimmune encephalomyelitis development.Journal of leukocyte biology · 2016Article
- Tumor-derived inducible heat-shock protein 70 (HSP70) is an essential component of anti-tumor immunity.Oncogene · 2015Article
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- Polyinosinic-polycytidylic acid has therapeutic effects against cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via TLR3.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell Types.Frontiers in immunology · 2014Review
- A systems biology approach to the analysis of subset-specific responses to lipopolysaccharide in dendritic cells.PloS one · 2014Article
- The effects of chemotherapeutic drugs on human monocyte-derived dendritic cell differentiation and antigen presentation.Clinical and experimental immunology · 2013Article
- A temporal role of type I interferon signaling in CD8+ T cell maturation during acute West Nile virus infection.PLoS pathogens · 2011Article
- Type I interferon is selectively required by dendritic cells for immune rejection of tumors.The Journal of experimental medicine · 2011Article
- Beta interferon controls West Nile virus infection and pathogenesis in mice.Journal of virology · 2011Article
- Hsp70 and its molecular role in nervous system diseases.Biochemistry research international · 2011Article
- High affinity binding of hydrophobic and autoantigenic regions of proinsulin to the 70 kDa chaperone DnaK.BMC biochemistry · 2010Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
Type I IFNs play a key role in linking the innate and adaptive arms of the immune system. Although produced rapidly in response to pathogens, IFNs are also produced at low levels in the absence of infection. In the present study, we demonstrate that constitutively produced IFNs are necessary in vivo to maintain dendritic cells in an "Ag presentation-competent" state. Conventional dendritic cells (cDCs) isolated from spleens of IFN-beta or IFNAR-deficient mice exhibit a highly impaired ability to present Ag and activate naive T cells. Microarray analysis of mRNA isolated from IFN-beta(-/-) and IFNAR(-/-) cDCs revealed diminished expression of two genes that encoded members of the heat shock protein 70 (Hsp70) family. Consistent with this observation, pharmacological inhibition of Hsp70 in cDCs from wild-type mice impaired their T cell stimulatory capacity. Similarly, the Ag presentation ability of splenic cDCs isolated from Hsp70.1/3(-/-) mice was also severely impaired in comparison to wild-type cDCs. Thus, constitutive IFN-beta expression regulates Hsp70 levels to help maintain dendritic cells in a competent state for efficient priming of effector T cells in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.