ArticleArchives of general psychiatry2009
Predictive value of family history on severity of illness: the case for depression, anxiety, alcohol dependence, and drug dependence.
Article in Archives of general psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
91 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Relationship Between Family History of Depression and Brain Structure and Function: A Systematic Review of Large Cohorts.Biological psychiatry · 2026Pooled it
- Prevalence of depression and its associated factors among Ethiopian students: a systematic review and meta-analysis.BMJ open · 2024Pooled it
- Prediction and diagnosis of depression using machine learning with electronic health records data: a systematic review.BMC medical informatics and decision making · 2023Pooled it
- Differences in Sociodemographic and Alcohol-Related Clinical Characteristics Between Treatment Seekers and Nontreatment Seekers and Their Role in Predicting Outcomes in the COMBINE Study for Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2020Trial
- Patterns, Predictors, and Correlates of Problematic Alcohol Use and Remission From Adolescence to Early Midlife.Alcohol, clinical & experimental research · 2026Article
- Why psychopathology research should avoid studying one mental disorder at a time: An intergenerational and developmental evidence base for understanding "p".Journal of psychopathology and clinical science · 2026Review
- Self-help group participation, avoidance of nonalcoholic beer, and nonsmoking independently predict better drinking outcomes in Japanese alcohol-dependent men.Alcohol, clinical & experimental research · 2026Article
- The nature and nurture of mental health problems in the family.PLoS medicine · 2026Article
- The Cumulative Risk of Having a Family Member With a Diagnosed Mental Disorder: A Nationwide Study of Mental Disorders in Family Networks.Acta psychiatrica Scandinavica · 2026Article
- DNA methylation profiles of long-term cannabis users in midlife: a comprehensive evaluation of published cannabis-associated methylation markers in a representative cohort.Molecular psychiatry · 2025Article
- Influence of tobacco smoking and alcohol drinking on anxiety in sample of 30 836 individuals in Taiwan Biobank.BJPsych open · 2025Article
- Prevalence of depressive symptoms and their determinants among adolescents in Can Tho City, Vietnam: A cross-sectional study.Global mental health (Cambridge, England) · 2025Article
- Identifying depression subtypes and investigating their consistency and transitions in a 1-year cohort analysis.PloS one · 2025Article
- A familial subtype of gambling disorder.Journal of behavioral addictions · 2024Article
- Alcohol use disorder and risk of specific methods of suicide death in a national cohort.Acta psychiatrica Scandinavica · 2024Article
- Pattern of Risks for Psychiatric and Substance Use Disorders in the Offspring of Parents With Alcohol Use Disorder.The American journal of psychiatry · 2024Article
- The Add Health Parent Study: A Biosocial Resource for the Study of Multigenerational Racial/Ethnic Disparities in Alzheimer's Disease and Alzheimer's Disease-Related Dementias.Journal of Alzheimer's disease : JAD · 2024Article
- Characterising depression trajectories in young people at high familial risk of depression.Journal of affective disorders · 2023Article
- Article
- Prevalence and associated factors of depression, anxiety, and stress among high school students in, Northwest Ethiopia, 2021.BMC psychiatry · 2022Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
contextIf family history is associated with clinical features that are thought to index seriousness of disorder, this could inform clinicians predicting patients' prognosis and researchers selecting cases for genetic studies. Although tests of associations between family history and clinical features are numerous for depression, such tests are relatively lacking for other disorders.
objectiveTo test the hypothesis that family history is associated with 4 clinical indexes of disorder (recurrence, impairment, service use, and age at onset) in relation to 4 psychiatric disorders (major depressive episode, anxiety disorder, alcohol dependence, and drug dependence).
designProspective longitudinal cohort study.
settingNew Zealand.
participantsA total of 981 members of the 1972 to 1973 Dunedin Study birth cohort (96% retention).
main outcome measuresFor each disorder, family history scores were calculated as the proportion of affected family members from data on 3 generations of the participants' families. Data collected prospectively at the study's repeated assessments (ages 11-32 years) were used to assess recurrence, impairment, and age at onset; data collected by means of a life history calendar at age 32 years were used to assess service use.
resultsFamily history was associated with the presence of all 4 disorder types. In addition, family history was associated with a more recurrent course for all 4 disorders (but not significantly for women with depression), worse impairment, and greater service use. Family history was not associated with younger age at onset for any disorder.
conclusionsAssociations between family history of a disorder and clinical features of that disorder in probands showed consistent direction of effects across depression, anxiety disorder, alcohol dependence, and drug dependence. For these disorder types, family history is useful for determining patients' clinical prognosis and for selecting cases for genetic studies.
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