ArticleAntimicrobial agents and chemotherapy2009
Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs.
Article in Antimicrobial agents and chemotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 68 citations in OpenAlex.
- Laboratory and field performance of 2-(thiocyanomethylthio)benzothiazole against fast-growing nontuberculous mycobacteria found in metalworking fluid.Journal of industrial microbiology & biotechnology · 2026Article
- Persistent Pathogens Following Minimally Invasive Surgery: Is It Time to Rethink Aldehyde-Based Disinfection?Cureus · 2025Article
- Label-Free Flow Cytometry: A Powerful Tool to Rapidly and Accurately Assess the Efficacy of Chemical Disinfectants.Microorganisms · 2025Article
- Review
- Disinfectants and antiseptics: mechanisms of action and resistance.Nature reviews. Microbiology · 2024Review
- Current Understanding of Potential Linkages between Biocide Tolerance and Antibiotic Cross-Resistance.Microorganisms · 2023Review
- Priming with biocides: A pathway to antibiotic resistance?Journal of applied microbiology · 2022Article
- The effect of disinfectants and antiseptics on co- and cross-selection of resistance to antibiotics in aquatic environments and wastewater treatment plants.Frontiers in microbiology · 2022Review
- Worldwide survey of Corynebacterium striatum increasingly associated with human invasive infections, nosocomial outbreak, and antimicrobial multidrug-resistance, 1976-2020.Archives of microbiology · 2021Review
- Increased Virulence of Outer Membrane Porin Mutants ofFrontiers in microbiology · 2021Article
- Tolerance to Glutaraldehyde inFrontiers in microbiology · 2021Article
- The conserved translation factor LepA is required for optimal synthesis of a porin family inJournal of bacteriology · 2020Article
- Biofilms of the non-tuberculousCell surface (Amsterdam, Netherlands) · 2020Article
- Article
- Mechanism and resistance for antimycobacterial activity of a fluoroquinophenoxazine compound.PloS one · 2019Article
- Resistance of Bacteria to Biocides.Microbiology spectrum · 2018Review
- Disinfectant Susceptibility Profiling of Glutaraldehyde-Resistant Nontuberculous Mycobacteria.Infection control and hospital epidemiology · 2017Article
- Genomic epidemiology of a national outbreak of post-surgicalMicrobial genomics · 2017Article
- Synthesis and antimicrobial activity of chiral quaternaryDrug design, development and therapy · 2017Article
- Outbreak of Hospital Infection from Biofilm-embedded Pan Drug-resistantJournal of preventive medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nosocomial outbreaks attributable to glutaraldehyde-resistant, rapidly growing mycobacteria are increasing. Here, evidence is provided that defects in porin expression dramatically increase the resistance of Mycobacterium smegmatis and Mycobacterium chelonae to glutaraldehyde and another aldehyde disinfectant, ortho-phthalaldehyde. Since defects in porin activity also dramatically increased the resistance of M. chelonae to drugs, there is thus some concern that the widespread use of glutaraldehyde and ortho-phthalaldehyde in clinical settings may select for drug-resistant bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.