ArticleGenetics2009
Splicing variation at a FLOWERING LOCUS C homeolog is associated with flowering time variation in the tetraploid Capsella bursa-pastoris.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Epilobieae genomes and the evolution of Myrtales.BMC plant biology · 2025Article
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- What can cold-induced transcriptomes of Arctic Brassicaceae tell us about the evolution of cold tolerance?Molecular ecology · 2022Article
- On the origin of the widespread self-compatible allotetraploid Capsella bursa-pastoris (Brassicaceae).Heredity · 2021Article
- Leaf senescence: progression, regulation, and application.Molecular horticulture · 2021Review
- The Transcriptional and Splicing Changes Caused by Hybridization Can Be Globally Recovered by Genome Doubling during Allopolyploidization.Molecular biology and evolution · 2021Article
- Investigation for a multi-silique trait inPeerJ · 2020Article
- Article
- RNA Splicing ofFrontiers in plant science · 2019Review
- Parallel Evolution of Common Allelic Variants Confers Flowering Diversity inThe Plant cell · 2018Article
- Changing Responses to Changing Seasons: Natural Variation in the Plasticity of Flowering Time.Plant physiology · 2017Review
- Habitat-Associated Life History and Stress-Tolerance Variation in Arabidopsis arenosa.Plant physiology · 2016Article
- The origin of exon 3 skipping of paternal GLOBOSA pre-mRNA in some Nicotiana tabacum lines correlates with a point mutation of the very last nucleotide of the exon.Molecular genetics and genomics : MGG · 2016Article
- Variation in the flowering time orthologs BrFLC and BrSOC1 in a natural population of Brassica rapa.PeerJ · 2015Article
- Alternative splicing of transcription factors in plant responses to low temperature stress: mechanisms and functions.Planta · 2013Review
- Independent FLC mutations as causes of flowering-time variation in Arabidopsis thaliana and Capsella rubella.Genetics · 2012Article
- A naturally occurring InDel variation in BraA.FLC.b (BrFLC2) associated with flowering time variation in Brassica rapa.BMC plant biology · 2012Article
- Co-adaptation of seed dormancy and flowering time in the arable weed Capsella bursa-pastoris (shepherd's purse).Annals of botany · 2012Article
- Natural variation in Arabidopsis: from molecular genetics to ecological genomics.Plant physiology · 2012Review
- Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The long-term fates of duplicate genes are well studied both empirically and theoretically, but how the short-term evolution of duplicate genes contributes to phenotypic variation is less well known. Here, we have studied the genetic basis of flowering time variation in the disomic tetraploid Capsella bursa-pastoris. We sequenced four duplicate candidate genes for flowering time and 10 background loci in samples from western Eurasia and China. Using a mixed-model approach that accounts for population structure, we found that polymorphisms at one homeolog of two candidate genes, FLOWERING LOCUS C (FLC) and CRYPTOCHROME1 (CRY1), were associated with natural flowering time variation. No potentially causative polymorphisms were found in the coding region of CRY1; however, at FLC two splice site polymorphisms were associated with early flowering. Accessions harboring nonconsensus splice sites expressed an alternatively spliced transcript or did not express this FLC homeolog. Our results are consistent with the function of FLC as a major repressor of flowering in Arabidopsis thaliana and imply that nonfunctionalization of duplicate genes could provide an important source of phenotypic variation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.