ArticleGenetics2009
The population genomics of trans-specific inversion polymorphisms in Anopheles gambiae.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Article
- Potential persistence mechanisms of the major Anopheles gambiae species complex malaria vectors in sub-Saharan Africa: a narrative review.Malaria journal · 2023Review
- Differing associations between sex determination and sex-linked inversions in two ecotypes ofEvolution letters · 2022Article
- Gene regulatory effects of a large chromosomal inversion in highland maize.PLoS genetics · 2020Article
- Linked-read sequencing identifies abundant microinversions and introgression in the arboviral vector Aedes aegypti.BMC biology · 2020Article
- Patterns of geographic variation of thermal adapted candidate genes in Drosophila subobscura sex chromosome arrangements.BMC evolutionary biology · 2018Article
- Massive introgression drives species radiation at the range limit of Anopheles gambiae.Scientific reports · 2017Article
- Chromosome inversions and ecological plasticity in the main African malaria mosquitoes.Evolution; international journal of organic evolution · 2017Article
- Understanding the DNA damage response in order to achieve desired gene editing outcomes in mosquitoes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Review
- Mosquito genomics. Extensive introgression in a malaria vector species complex revealed by phylogenomics.Science (New York, N.Y.) · 2015Article
- Article
- Cuticular differences associated with aridity acclimation in African malaria vectors carrying alternative arrangements of inversion 2La.Parasites & vectors · 2014Article
- Diversity, differentiation, and linkage disequilibrium: prospects for association mapping in the malaria vector Anopheles arabiensis.G3 (Bethesda, Md.) · 2014Article
- Adaptation through chromosomal inversions in Anopheles.Frontiers in genetics · 2014Review
- Assessing when chromosomal rearrangements affect the dynamics of speciation: implications from computer simulations.Frontiers in genetics · 2014Article
- Spatiotemporal dynamics of gene flow and hybrid fitness between the M and S forms of the malaria mosquito, Anopheles gambiae.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Distinct population structure for co-occurring Anopheles goeldii and Anopheles triannulatus in Amazonian Brazil.Memorias do Instituto Oswaldo Cruz · 2013Article
- An analysis of two island groups as potential sites for trials of transgenic mosquitoes for malaria control.Evolutionary applications · 2013Article
- Patterns of genetic variation across inversions: geographic variation in the In(2L)t inversion in populations of Drosophila melanogaster from eastern Australia.BMC evolutionary biology · 2013Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
In the malaria mosquito Anopheles gambiae polymorphic chromosomal inversions may play an important role in adaptation to environmental variation. Recently, we used microarray-based divergence mapping combined with targeted resequencing to map nucleotide differentiation between alternative arrangements of the 2La inversion. Here, we applied the same technique to four different polymorphic inversions on the 2R chromosome of An. gambiae. Surprisingly, divergence was much lower between alternative arrangements for all 2R inversions when compared to the 2La inversion. For one of the rearrangements, 2Ru, we successfully mapped a very small region (approximately 100 kb) of elevated divergence. For the other three rearrangements, we did not identify any regions of significantly high divergence, despite ample independent evidence from natural populations of geographic clines and seasonal cycling, and stable heterotic polymorphisms in laboratory populations. If these inversions are the targets of selection as hypothesized, we suggest that divergence between rearrangements may have escaped detection due to retained ancestral polymorphism in the case of the youngest 2R rearrangements and to extensive gene flux in the older 2R inversion systems that segregate in both An. gambiae and its sibling species An. arabiensis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.