ArticleEukaryotic cell2009
DYF-1 Is required for assembly of the axoneme in Tetrahymena thermophila.
Article in Eukaryotic cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- A practical reference for studying meiosis in the model ciliateMarine life science & technology · 2022Review
- The physiological cargo adaptor of kinesin-2 functions as an evolutionary conserved lockpick.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- STORM imaging reveals the spatial arrangement of transition zone components and IFT particles at the ciliary base in Tetrahymena.Scientific reports · 2021Article
- Ccdc113/Ccdc96 complex, a novel regulator of ciliary beating that connects radial spoke 3 to dynein g and the nexin link.PLoS genetics · 2021Article
- LF4/MOK and a CDK-related kinase regulate the number and length of cilia in Tetrahymena.PLoS genetics · 2019Article
- Ultrastructural Studies on a Model Tintinnid -Acta protozoologica · 2019Article
- Motile Cilia: Innovation and Insight From Ciliate Model Organisms.Frontiers in cell and developmental biology · 2019Review
- Tetrahymena RIB72A and RIB72B are microtubule inner proteins in the ciliary doublet microtubules.Molecular biology of the cell · 2018Article
- Posttranslational Modifications of Tubulin and Cilia.Cold Spring Harbor perspectives in biology · 2017Review
- Article
- Kinesin-13 regulates the quantity and quality of tubulin inside cilia.Molecular biology of the cell · 2015Article
- Total internal reflection fluorescence microscopy of intraflagellar transport in Tetrahymena thermophila.Methods in cell biology · 2015Article
- Crystal structures of IFT70/52 and IFT52/46 provide insight into intraflagellar transport B core complex assembly.The Journal of cell biology · 2014Article
- Article
- Architecture and function of IFT complex proteins in ciliogenesis.Differentiation; research in biological diversity · 2012Review
- Dissecting the sequential assembly and localization of intraflagellar transport particle complex B in Chlamydomonas.PloS one · 2012Article
- Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins.Molecular biology of the cell · 2011Article
- Ciliogenesis: building the cell's antenna.Nature reviews. Molecular cell biology · 2011Review
- Tubulin tyrosine ligase-like genes ttll3 and ttll6 maintain zebrafish cilia structure and motility.The Journal of biological chemistry · 2011Article
- Biochemical analysis of PIFTC3, the Trypanosoma brucei orthologue of nematode DYF-13, reveals interactions with established and putative intraflagellar transport components.Molecular microbiology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In most cilia, the axoneme can be subdivided into three segments: proximal (the transition zone), middle (with outer doublet microtubules), and distal (with singlet extensions of outer doublet microtubules). How the functionally distinct segments of the axoneme are assembled and maintained is not well understood. DYF-1 is a highly conserved ciliary protein containing tetratricopeptide repeats. In Caenorhabditis elegans, DYF-1 is specifically needed for assembly of the distal segment (G. Ou, O. E. Blacque, J. J. Snow, M. R. Leroux, and J. M. Scholey. Nature. 436:583-587, 2005). We show that Tetrahymena cells lacking an ortholog of DYF-1, Dyf1p, can assemble only extremely short axoneme remnants that have structural defects of diverse natures, including the absence of central pair and outer doublet microtubules and incomplete or absent B tubules on the outer microtubules. Thus, in Tetrahymena, DYF-1 is needed for either assembly or stability of the entire axoneme. Our observations support the conserved function for DYF-1 in axoneme assembly or stability but also show that the consequences of loss of DYF-1 for axoneme segments are organism specific.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.