ArticleJournal of bacteriology2009
Bifurcated degradative pathway of 3-sulfolactate in Roseovarius nubinhibens ISM via sulfoacetaldehyde acetyltransferase and (S)-cysteate sulfolyase.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Bacterial sulfoquinovose cycling across aquatic ecosystems.FEMS microbiology reviews · 2026Review
- Assessing the Plastisphere from Floating Plastics in the Northwestern Mediterranean Sea, with Emphasis on Viruses.Microorganisms · 2024Article
- Molecular basis of sulfolactate synthesis by sulfolactaldehyde dehydrogenase fromChemical science · 2023Article
- Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut.Nature communications · 2023Article
- Bacterial transcriptional response to labile exometabolites from photosynthetic picoeukaryote Micromonas commoda.ISME communications · 2023Article
- Genome sequences of Arthrobacter spp. that use a modified sulfoglycolytic Embden-Meyerhof-Parnas pathway.Archives of microbiology · 2022Article
- Newly Discovered AqE Gene is Highly Conserved in Non-tetrapod Vertebrates.Journal of molecular evolution · 2021Article
- Two radical-dependent mechanisms for anaerobic degradation of the globally abundant organosulfur compound dihydroxypropanesulfonate.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Sulfonate-based networks between eukaryotic phytoplankton and heterotrophic bacteria in the surface ocean.Nature microbiology · 2019Article
- Anaerobic Degradation of the Plant Sugar Sulfoquinovose Concomitant With HFrontiers in microbiology · 2018Article
- Tripartite ATP-Independent Periplasmic (TRAP) Transporters and Tripartite Tricarboxylate Transporters (TTT): From Uptake to Pathogenicity.Frontiers in cellular and infection microbiology · 2018Review
- Bacterial transcriptome remodeling during sequential co-culture with a marine dinoflagellate and diatom.The ISME journal · 2017Article
- The life sulfuric: microbial ecology of sulfur cycling in marine sediments.Environmental microbiology reports · 2017Review
- Phylogenomics of Rhodobacteraceae reveals evolutionary adaptation to marine and non-marine habitats.The ISME journal · 2017Article
- Deciphering ocean carbon in a changing world.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Entner-Doudoroff pathway for sulfoquinovose degradation in Pseudomonas putida SQ1.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Cryptic carbon and sulfur cycling between surface ocean plankton.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- An Updated genome annotation for the model marine bacterium Ruegeria pomeroyi DSS-3.Standards in genomic sciences · 2014Article
- Homotaurine metabolized to 3-sulfopropanoate in Cupriavidus necator H16: enzymes and genes in a patchwork pathway.Journal of bacteriology · 2009Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Data from the genome sequence of the aerobic, marine bacterium Roseovarius nubinhibens ISM were interpreted such that 3-sulfolactate would be degraded as a sole source of carbon and energy for growth via a novel bifurcated pathway including two known desulfonative enzymes, sulfoacetaldehyde acetyltransferase (EC 2.3.3.15) (Xsc) and cysteate sulfo-lyase (EC 4.4.1.25) (CuyA). Strain ISM utilized sulfolactate quantitatively with stoichiometric excretion of the sulfonate sulfur as sulfate. A combination of enzyme assays, analytical chemistry, enzyme purification, peptide mass fingerprinting, and reverse transcription-PCR data supported the presence of an inducible, tripartite sulfolactate uptake system (SlcHFG), and a membrane-bound sulfolactate dehydrogenase (SlcD) which generated 3-sulfopyruvate, the point of bifurcation. 3-Sulfopyruvate was in part decarboxylated by 3-sulfopyruvate decarboxylase (EC 4.1.1.79) (ComDE), which was purified. The sulfoacetaldehyde that was formed was desulfonated by Xsc, which was identified, and the acetyl phosphate was converted to acetyl-coenzyme A by phosphate acetyltransferase (Pta). The other portion of the 3-sulfopyruvate was transaminated to (S)-cysteate, which was desulfonated by CuyA, which was identified. The sulfite that was formed was presumably exported by CuyZ (TC 9.B.7.1.1 in the transport classification system), and a periplasmic sulfite dehydrogenase is presumed. Bioinformatic analyses indicated that transporter SlcHFG is rare but that SlcD is involved in three different combinations of pathways, the bifurcated pathway shown here, via CuyA alone, and via Xsc alone. This novel pathway involves ComDE in biodegradation, whereas it was discovered in the biosynthesis of coenzyme M. The different pathways of desulfonation of sulfolactate presumably represent final steps in the biodegradation of sulfoquinovose (and exudates derived from it) in marine and aquatic environments.
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