ArticleThe Journal of biological chemistry2009
Modulation of calcium oxalate dihydrate growth by selective crystal-face binding of phosphorylated osteopontin and polyaspartate peptide showing occlusion by sectoral (compositional) zoning.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 73 citations in OpenAlex.
- Review
- Annexin-derived self-assembling peptide nanostructures for alleviation of calcium oxalate -induced renal injury.Urolithiasis · 2024Article
- Ab Initio Molecular Dynamics Simulations of Phosphocholine Interactions with a Calcium Oxalate Dihydrate (110) Surface.Crystal growth & design · 2024Article
- The impact of crystal phase transition on the hardness and structure of kidney stones.Urolithiasis · 2024Article
- Increased abundance of bacteria of the family Muribaculaceae achieved by fecal microbiome transplantation correlates with the inhibition of kidney calcium oxalate stone deposition in experimental rats.Frontiers in cellular and infection microbiology · 2023Article
- Multicolor imaging of calcium-binding proteins in human kidney stones for elucidating the effects of proteins on crystal growth.Scientific reports · 2021Article
- Intrinsically Disordered Osteopontin Fragment Orders During Interfacial Calcium Oxalate Mineralization.Angewandte Chemie (International ed. in English) · 2021Article
- Developments and Ongoing Challenges for Analysis of Surface-Bound Proteins.Annual review of analytical chemistry (Palo Alto, Calif.) · 2021Article
- Human kidney stones: a natural record of universal biomineralization.Nature reviews. Urology · 2021Review
- Article
- Ptychographic X-ray tomography reveals additive zoning in nanocomposite single crystals.Chemical science · 2020Article
- In Vitro Studies Reveal Antiurolithic Effect of Antioxidant Sulfated Polysaccharides from the Green SeaweedMarine drugs · 2019Article
- Peptide-Controlled Assembly of Macroscopic Calcium Oxalate Nanosheets.The journal of physical chemistry letters · 2019Article
- 3D visualization of additive occlusion and tunable full-spectrum fluorescence in calcite.Nature communications · 2016Article
- Exploring calcium oxalate crystallization: a constant composition approach.Urolithiasis · 2015Article
- Biomimetic synthesis of struvite with biogenic morphology and implication for pathological biomineralization.Scientific reports · 2015Article
- Induced urinary crystal formation as an analytical strategy for the prediction and monitoring of urolithiasis and other metabolism-related disorders.The EPMA journal · 2014Review
- Revisiting the Fundamentals in the Design and Control of Nanoparticulate Colloids in the Frame of Soft Chemistry.Review journal of chemistry · 2013Article
- Biomolecular mechanism of urinary stone formation involving osteopontin.Urological research · 2012Review
- Relative deficiency of acidic isoforms of osteopontin from stone former urine.Urological research · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium oxalate dihydrate (COD) mineral and the urinary protein osteopontin/uropontin (OPN) are commonly found in kidney stones. To investigate the effects of OPN on COD growth, COD crystals were grown with phosphorylated OPN or a polyaspartic acid-rich peptide of OPN (DDLDDDDD, poly-Asp(86-93)). Crystals grown with OPN showed increased dimensions of the {110} prismatic faces attributable to selective inhibition at this crystallographic face. At high concentrations of OPN, elongated crystals with dominant {110} faces were produced, often with intergrown, interpenetrating twin crystals. Poly-Asp(86-93) dose-dependently elongated crystal morphology along the {110} faces in a manner similar to OPN. In crystal growth studies using fluorescently tagged poly-Asp(86-93) followed by imaging of crystal interiors using confocal microscopy, sectoral (compositional) zoning in COD was observed resulting from selective binding and incorporation (occlusion) of peptide exclusively into {110} crystal sectors. Computational modeling of poly-Asp(86-93) adsorption to COD {110} and {101} surfaces also suggests increased stabilization of the COD {110} surface and negligible change to the natively stable {101} surface. Ultrastructural, colloidal-gold immunolocalization of OPN by transmission electron microscopy in human stones confirmed an intracrystalline distribution of OPN. In summary, OPN and its poly-Asp(86-93) sequence similarly affect COD mineral growth; the {110} crystallographic faces become enhanced and dominant attributable to {110} face inhibition by the protein/peptide, and peptides can incorporate into the mineral phase. We, thus, conclude that the poly-Asp(86-93) domain is central to the OPN ability to interact with the {110} faces of COD, where it binds to inhibit crystal growth with subsequent intracrystalline incorporation (occlusion).
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