ArticleThe Journal of biological chemistry2009
In vivo mutational analysis of YtvA from Bacillus subtilis: mechanism of light activation of the general stress response.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets.FEBS letters · 2026Review
- Light Control in Microbial Systems.International journal of molecular sciences · 2024Review
- The circadian clock of the bacteriumScience advances · 2023Article
- Signal transduction in light-oxygen-voltage receptors lacking the active-site glutamine.Nature communications · 2022Article
- Dimeric allostery mechanism of the plant circadian clock photoreceptor ZEITLUPE.PLoS computational biology · 2021Article
- Steric and Electronic Interactions at Gln154 in ZEITLUPE Induce Reorganization of the LOV Domain Dimer Interface.Biochemistry · 2021Article
- Article
- Bacterial cell growth is arrested by violet and blue, but not yellow light excitation during fluorescence microscopy.BMC molecular and cell biology · 2020Article
- Flavin-Based Fluorescent Protein EcFbFP Auto-Guided Surface Display of Methyl Parathion Hydrolase in Escherichia coli.Molecular biotechnology · 2019Article
- Programming Bacteria With Light-Sensors and Applications in Synthetic Biology.Frontiers in microbiology · 2018Review
- Blue-Light Inhibition of Listeria monocytogenes Growth Is Mediated by Reactive Oxygen Species and Is Influenced by σB and the Blue-Light Sensor Lmo0799.Applied and environmental microbiology · 2016Article
- The Role of Stress and Stress Adaptations in Determining the Fate of the Bacterial PathogenFrontiers in microbiology · 2016Review
- Structure and function of a short LOV protein from the marine phototrophic bacterium Dinoroseobacter shibae.BMC microbiology · 2015Article
- LucY: A Versatile New Fluorescent Reporter Protein.PloS one · 2015Article
- Light-induced structural changes in a short light, oxygen, voltage (LOV) protein revealed by molecular dynamics simulations-implications for the understanding of LOV photoactivation.Frontiers in molecular biosciences · 2015Article
- LOV-based optogenetic devices: light-driven modules to impart photoregulated control of cellular signaling.Frontiers in molecular biosciences · 2015Review
- From Plant Infectivity to Growth Patterns: The Role of Blue-Light Sensing in the Prokaryotic World.Plants (Basel, Switzerland) · 2014Review
- Genetic evidence for a phosphorylation-independent signal transduction mechanism within the Bacillus subtilis stressosome.PloS one · 2014Article
- Cycles of light and dark co-ordinate reversible colony differentiation in Listeria monocytogenes.Molecular microbiology · 2013Article
- Light-induced subunit dissociation by a light-oxygen-voltage domain photoreceptor from Rhodobacter sphaeroides.Biochemistry · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The general stress response of Bacillus subtilis can be activated by stimuli such as the addition of salt or ethanol and with blue light. In the latter response, YtvA activates sigma(B) through a cascade of Rsb proteins, organized in stressosomes. YtvA is composed of an N-terminal LOV (light, oxygen, and voltage) domain and a C-terminal STAS (sulfate transporter and anti-sigma factor) domain and shows light-modulated GTP binding in vitro. Here, we examine the mechanism of YtvA-mediated activation of sigma(B) in vivo with site-directed mutagenesis. Constitutive off and constitutive on mutations have been identified. Disruption of GTP binding in the STAS domain eliminates light activation of sigma(B). In contrast, modification of sites relevant for phosphorylation of STAS domains does not affect the stress response significantly. The data obtained are integrated into a model for the structure of full-length YtvA, which presumably functions as a dimer.
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