ReviewDrug discovery today2009
The impact of synthetic biology on drug discovery.
Review in Drug discovery today, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Chemically synthesized high-fidelity oligos ≤ 600 nt as building blocks to accelerate complex gene construction in synthetic biology.Synthetic biology (Oxford, England) · 2026Article
- A synthetic free fatty acid-regulated transgene switch in mammalian cells and mice.Nucleic acids research · 2018Article
- Bioactivity-Guided Fractionation of Pine Needle Reveals Catechin as an Anti-hypertension Agent via Inhibiting Angiotensin-Converting Enzyme.Scientific reports · 2017Article
- Recent Advances in the Recombinant Biosynthesis of Polyphenols.Frontiers in microbiology · 2017Review
- Precision multidimensional assay for high-throughput microRNA drug discovery.Nature communications · 2016Article
- Systematic transfer of prokaryotic sensors and circuits to mammalian cells.ACS synthetic biology · 2014Article
- Rationally designed bidirectional promoter improves the evolutionary stability of synthetic genetic circuits.Nucleic acids research · 2013Article
- Synergistic Synthetic Biology: Units in Concert.Frontiers in bioengineering and biotechnology · 2013Review
- Revisiting lab-on-a-chip technology for drug discovery.Nature reviews. Drug discovery · 2012Review
- Synthetic biology: mapping the scientific landscape.PloS one · 2012Article
- Emerging biomedical applications of synthetic biology.Nature reviews. Genetics · 2011Review
- Metabolic engineering for production of biorenewable fuels and chemicals: contributions of synthetic biology.Journal of biomedicine & biotechnology · 2010Review
- Computer-aided design of biological circuits using TinkerCell.Bioengineered bugsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of synthetic biology is holding great hopes for providing solutions to the unmet needs of humankind. This review article describes how synthetic biology can deliver on this promise in the field of drug discovery by providing novel opportunities throughout the entire drug discovery process. Synthetic biology tools enable disease mechanisms and target identification to be elucidated and also provide avenues to discover small chemotherapeutic molecules or design novel biopharmaceuticals. Furthermore, synthetic biologists can design cost-effective microbial production processes for complex natural products, which could help overcome global drug shortages. These impressive advances have been achieved in only a few years, and are an indicator for the potential of synthetic biology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.