ArticleExperimental gerontology2009
Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans.
Article in Experimental gerontology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
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- Acute Toxicity Evaluation of Phosphatidylcholine Nanoliposomes Containing Nisin inMolecules (Basel, Switzerland) · 2023Article
- Characterization of Stress Responses in aBiomolecules · 2021Article
- Parental breeding age effects on descendants' longevity interact over 2 generations in matrilines and patrilines.PLoS biology · 2019Article
- Resistance to Stress Can Be Experimentally Dissociated From Longevity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Measuring and modeling interventions in aging.Current opinion in cell biology · 2018Review
- Article
- Article
- Anthocyanin-rich tea Sunrouge upregulates expressions of heat shock proteins in the gastrointestinal tract of ICR mice: A comparison with the conventional tea cultivar Yabukita.Journal of food and drug analysis · 2015Article
- Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS).Dose-response : a publication of International Hormesis Society · 2014Article
- Lifespan and aggregate size variables in specifications of mortality or survivorship.PloS one · 2014Article
- A cytoprotective perspective on longevity regulation.Trends in cell biology · 2013Review
- Protein homeostasis, aging and Alzheimer's disease.Molecular neurobiology · 2012Review
- Article
- Longevity and stress in Caenorhabditis elegans.Aging · 2011Review
- OASIS: online application for the survival analysis of lifespan assays performed in aging research.PloS one · 2011Article
- Developmental biomarkers of aging in Caenorhabditis elegans.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Review
- Enhancing and Extending Biological Performance and Resilience.Dose-response : a publication of International Hormesis SocietyReview
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Exposure to mild heat-stress (heat-shock) can significantly increase the life expectancy of the nematode Caenorhabditis elegans. A single heat-shock early in life extends longevity by 20% or more and affects life-long mortality by decreasing initial mortality only; the rate of increase in subsequent mortality (Gompertz component) is unchanged. Repeated mild heat-shocks throughout life have a larger effect on life span than does a single heat-shock early in life. Here, we ask how multiple heat-shocks affect the mortality trajectory in nematodes and find increases of life expectancy of close to 50% and of maximum longevity as well. We examined mortality using large numbers of animals and found that multiple heat-shocks not only decrease initial mortality, but also slow the Gompertz rate of increase in mortality. Thus, multiple heat-shocks have anti-aging hormetic effects and represent an effective approach for modulating aging.
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Registered trials
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