ArticleRadiation research2009
Bystander effects induced by diffusing mediators after photodynamic stress.
Article in Radiation research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 61 citations in OpenAlex.
- Bystander effects in photodynamic therapy-treated tumors involve spatiotemporally extended ferroptosis.Journal of molecular medicine (Berlin, Germany) · 2026Review
- DNA Damage and Skin Injuries Caused by Ionizing Radiation and Strategies for Wound Healing.Progress in molecular and subcellular biology · 2026Review
- Recent strides in macromolecular targeted photodynamic therapy for cancer.Current opinion in chemical biology · 2024Review
- Upregulation of iNOS/NO in Cancer Cells That Survive a Photodynamic Challenge: Role of No in Accelerated Cell Migration and Invasion.International journal of molecular sciences · 2024Review
- Pro-Tumor Activity of Endogenous Nitric Oxide in Anti-Tumor Photodynamic Therapy: Recently Recognized Bystander Effects.International journal of molecular sciences · 2023Review
- Understanding the Photodynamic Therapy Induced Bystander and Abscopal Effects: A Review.Antioxidants (Basel, Switzerland) · 2023Review
- Article
- Photodynamic Therapy as an Oxidative Anti-Tumor Modality: Negative Effects of Nitric Oxide on Treatment Efficacy.Pharmaceutics · 2021Review
- Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors.BioMed research international · 2021Review
- Nitric Oxide-Mediated Resistance to Antitumor Photodynamic Therapy.Photochemistry and photobiology · 2020Review
- Local and Systemic Antitumor Effects of Photo-activatable Paclitaxel Prodrug on Rat Breast Tumor Models.Photochemistry and photobiology · 2020Article
- Bystander Effects of Nitric Oxide in Cellular Models of Anti-Tumor Photodynamic Therapy.Cancers · 2019Article
- Nitric Oxide Antagonism to Anti-Glioblastoma Photodynamic Therapy: Mitigation by Inhibitors of Nitric Oxide Generation.Cancers · 2019Review
- DirectRedox biology · 2017Review
- On the in vivo photochemical rate parameters for PDT reactive oxygen species modeling.Physics in medicine and biology · 2017Review
- Bystander effects of nitric oxide in anti-tumor photodynamic therapy.Cancer cell & microenvironment · 2017Article
- Bystander signaling via oxidative metabolism.OncoTargets and therapy · 2017Review
- Review
- Anticancer drug released from near IR-activated prodrug overcomes spatiotemporal limits of singlet oxygen.Bioorganic & medicinal chemistry · 2016Article
- High dose bystander effects in spatially fractionated radiation therapy.Cancer letters · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The bystander effect, whereby cells that are not traversed by ionizing radiation exhibit various responses when in proximity to irradiated cells, is well documented in the field of radiation biology, Here we demonstrate that considerable bystander responses are also observed after photodynamic stress using the membrane-localizing dye deuteroporphyrin (DP). Using cells of a WTK1 human lymphoblastoid cell line in suspension and a transwell insert system that precludes contact between targeted and bystander cells, we have shown that the bystander signaling is mediated by diffusing species. The extranuclear localization of the photosensitizer used suggests that primary DNA damage is not the trigger for initiating these bystander responses, which include elevated oxidative stress, DNA damage (micronucleus formation), mutagenesis and decreased clonogenic survival. In addition, oxidative stress in the bystander population was reduced by the presence of the membrane antioxidant vitamin E in the targeted cells, suggesting that lipid peroxidation may play a key role in mediating these bystander effects. The fluence responses for these bystander effects are non-linear, with larger effects seen at lower fluences and toxicity to the target cell population. Hence, when considering outcomes of photodynamic action in cells and tissue, bystander effects may be significant, especially at sublethal fluences.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.