ReviewRegenerative medicine2009
Emerging concepts in engineering extracellular matrix variants for directing cell phenotype.
Review in Regenerative medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- The Use of Small-Molecule Compounds for Cell Adhesion and Migration in Regenerative Medicine.Biomedicines · 2023Review
- Human Acellular Dermal Matrix in Reconstructive Surgery-A Review.Biomedicines · 2022Review
- Heterotypic Multicellular Spheroids as Experimental and Preclinical Models of Sprouting Angiogenesis.Biology · 2021Review
- Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds.Nanomaterials (Basel, Switzerland) · 2020Article
- Article
- Material Strategies for Modulating Epithelial to Mesenchymal Transitions.ACS biomaterials science & engineering · 2018Article
- Integrin α3β1 Binding to Fibronectin Is Dependent on the Ninth Type III Repeat.The Journal of biological chemistry · 2015Article
- Learning from nature - novel synthetic biology approaches for biomaterial design.Acta biomaterialia · 2014Review
- Article
- RGD surface functionalization of the hydrophilic acrylic intraocular lens material to control posterior capsular opacification.PloS one · 2014Article
- Hydroxyapatite nanoparticle reinforced peptide amphiphile nanomatrix enhances the osteogenic differentiation of mesenchymal stem cells by compositional ratios.Acta biomaterialia · 2012Article
- Collagen scaffolds with or without the addition of RGD peptides support cardiomyogenesis after aggregation of mouse embryonic stem cells.In vitro cellular & developmental biology. Animal · 2011Article
- Evolving the use of peptides as components of biomaterials.Biomaterials · 2011Article
- Extracellular matrix proteases contribute to progression of pelvic organ prolapse in mice and humans.The Journal of clinical investigation · 2011Article
- Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices.Integrative biology : quantitative biosciences from nano to macro · 2011Article
- Guiding epithelial cell phenotypes with engineered integrin-specific recombinant fibronectin fragments.Tissue engineering. Part A · 2011Article
- Multi-component extracellular matrices based on peptide self-assembly.Chemical Society reviews · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Directing specific, complex cell behaviors, such as differentiation, in response to biomaterials for regenerative medicine applications is, at present, a mostly unrealized goal. To date, current technological advances have been inspired by the reductionist point of view, focused on developing simple and merely adequate environments that facilitate simple cellular adhesion. However, even if extracellular matrix (ECM)-derived peptides, such as Arg-Gly-Asp (RGD), have largely demonstrated their utility in supporting cell adhesion, their lack of biological specificity is simply not optimal for controlling more integrated processes, such as cell differentiation. These more complex cellular processes require specific integrin-signaling scaffolds and presumably synergistic integrin and growth factor-receptor signaling. This article will introduce some current efforts to engineer ECM variants that incorporate additional levels of complexity for directing greater integrin specificity and synergistic ECM growth factor signaling toward directing cell phenotype.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.