ArticleThe European physical journal. E, Soft matter2009
Physical model for the width distribution of axons.
Article in The European physical journal. E, Soft matter, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- The role of mechanics in axonal stability and development.Seminars in cell & developmental biology · 2023Review
- Article
- Parametric Probability Distribution Functions for Axon Diameters of Corpus Callosum.Frontiers in neuroanatomy · 2016Article
- An optimum principle predicts the distribution of axon diameters in normal white matter.PloS one · 2013Article
- Size of cell-surface Kv2.1 domains is governed by growth fluctuations.Biophysical journal · 2012Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
The distribution of widths of axons was recently investigated, and was found to have a distinct peak at an optimized value. The optimized axon width at the peak may arise from the conflicting demands of minimizing energy consumption and assuring signal transmission reliability. The distribution around this optimized value is found to have a distinct non-Gaussian shape, with an exponential "tail". We propose here a mechanical model whereby this distribution arises from the interplay between the elastic energy of the membrane surrounding the axon core, the osmotic pressure induced by the neurofilaments inside the axon bulk, and active processes that remodel the microtubules and neurofilaments inside the axon. The axon's radius of curvature can be determined by the cell's control of the osmotic pressure difference across the membrane, the membrane tension or by changing the composition of the different components of the membrane. We find that the osmotic pressure, determined by the neurofilaments, seems to be the dominant control parameter.
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