ArticleEuropean biophysics journal : EBJ2009
Critical stresses for cancer cell detachment in microchannels.
Article in European biophysics journal : EBJ, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Trade-off movement between hydraulic resistance escape and shear stress escape by cancer cells.Biophysical journal · 2025Article
- Quantifying the mechanics of locomotion of the schistosome pathogen with respect to changes in its physical environment.Journal of the Royal Society, Interface · 2019Article
- Biophysics of Cell-Substrate Interactions Under Shear.Frontiers in cell and developmental biology · 2019Review
- Correlation ofRSC advances · 2018Article
- Hemodynamic shear stress induces protective autophagy in HeLa cells through lipid raft-mediated mechanotransduction.Clinical & experimental metastasis · 2018Article
- A microfluidic platform for drug screening in a 3D cancer microenvironment.Biosensors & bioelectronics · 2017Article
- Microfluidic Biopsy Trapping Device for the Real-Time Monitoring of Tumor Microenvironment.PloS one · 2017Article
- Modulating wall shear stress gradient via equilateral triangular channel forBiomicrofluidics · 2016Article
- Quantifying cell adhesion through impingement of a controlled microjet.Biophysical journal · 2015Article
- Perspective: Flicking with flow: Can microfluidics revolutionize the cancer research?Biomicrofluidics · 2013Article
- Single-cell measurements of IgE-mediated FcεRI signaling using an integrated microfluidic platform.PloS one · 2013Article
- A low-dimensional deformation model for cancer cells in flow.Physics of fluids (Woodbury, N.Y. : 1994) · 2012Article
- Partial transfection of cells using laminar flows in microchannels.Biomicrofluidics · 2011Article
- Guiding neuron development with planar surface gradients of substrate cues deposited using microfluidic devices.Lab on a chip · 2010Article
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Authors and funding
3 authors.
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Abstract
We present experiments involving cancer cells adhering to microchannels, subjected to increasing shear stresses (0.1-30 Pa). Morphological studies were carried out at different shear stresses. Cells exhibit spreading patterns similar to those observed under static conditions, as long as the shear stress is not too high. At critical wall shear stresses (around 2-5 Pa), cell-substrate contact area decreases until detachment at the larger stresses. Critical shear stresses are found to be lower for higher confinements (i.e. smaller cell height to channel height ratio). Fluorescent techniques were used to locate focal adhesions (typically 1 lm(2) in size) under various shearing conditions, showing that cells increase the number of focal contacts in the region facing the flow. To analyze such data, we propose a model to determine the critical stress, resulting from the competition between hydrodynamic forces and the adhesive cell resistance. With this model, typical adhesive stresses exerted at each focal contact can be determined and are in agreement with previous works.
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