ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2010
Lifetime- and caste-specific changes in flight metabolic rate and muscle biochemistry of honeybees, Apis mellifera.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 69 citations in OpenAlex.
- Article
- Comprehension of the age-dependent gut and brain interaction of honey bee workers by integration of multi omics approaches.Journal of advanced research · 2026Article
- Neurotranscriptomic profiling of deformed wing virus-infected honey bee foragers (Apis mellifera) with different cognitive abilities.Biology open · 2025Article
- The Efficiency of the Krebs Cycle and the Respiratory Chain in Physiologically and Prematurely Aging Bees (International journal of molecular sciences · 2025Article
- Insect Flight Energetics and the Evolution of Size, Form, and Function.Integrative and comparative biology · 2024Review
- Developmental biomechanics and age polyethism in leaf-cutter ants.Proceedings. Biological sciences · 2023Article
- Chronic Effects of Imidacloprid on Honey Bee Worker Development-Molecular Pathway Perspectives.International journal of molecular sciences · 2021Review
- Brain Size, Metabolism, and Social Evolution.Frontiers in physiology · 2021Article
- Honeybee lifespan: the critical role of pre-foraging stage.Royal Society open science · 2020Article
- Weight of evidence evaluation of a network of adverse outcome pathways linking activation of the nicotinic acetylcholine receptor in honey bees to colony death.The Science of the total environment · 2017Review
- Flight behaviour of honey bee (Apis mellifera) workers is altered by initial infections of the fungal parasite Nosema apis.Scientific reports · 2016Article
- Flight performance of actively foraging honey bees is reduced by a common pathogen.Environmental microbiology reports · 2016Article
- Effects of ambient and preceding temperatures and metabolic genes on flight metabolism in the Glanville fritillary butterfly.Journal of insect physiology · 2016Article
- Rapid behavioral maturation accelerates failure of stressed honey bee colonies.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Effects of Increased Flight on the Energetics and Life History of the Butterfly Speyeria mormonia.PloS one · 2015Article
- A review of the energetics of pollination biology.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2013Review
- Changes in mitochondrial energy utilization in young and old worker honeybees (Apis mellifera).Age (Dordrecht, Netherlands) · 2013Article
- The use of honeybees reared in a thermostatic chamber for aging studies.Age (Dordrecht, Netherlands) · 2013Article
- Effects of Flight on Gene Expression and Aging in the Honey Bee Brain and Flight Muscle.Insects · 2012Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Honeybees, Apis mellifera, who show temporal polyethism, begin their adult life performing tasks inside the hive (hive bees) and then switch to foraging when they are about 2-3 weeks old (foragers). Usually hive tasks require little or no flying, whereas foraging involves flying for several hours a day and carrying heavy loads of nectar and pollen. Flight muscles are particularly plastic organs that can respond to use and disuse, and accordingly it would be expected that adjustments in flight muscle metabolism occur throughout a bee's life. We thus investigated changes in lifetime flight metabolic rate and flight muscle biochemistry of differently aged hive bees and of foragers with varying foraging experience. Rapid increases in flight metabolic rates early in life coincided with a switch in troponin T isoforms and increases in flight muscle maximal activities (V (max)) of the enzymes citrate synthase, cytochrome c oxidase, hexokinase, phosphofructokinase, and pyruvate kinase. However, further increases in flight metabolic rate in experienced foragers occurred without additional changes in the in vitro V (max) of these flight muscle metabolic enzymes. Estimates of in vivo flux (v) compared to maximum flux of each enzyme in vitro (fractional velocity, v/V (max)) suggest that most enzymes operate at a higher fraction of V (max) in mature foragers compared to young hive bees. Our results indicate that honeybees develop most of their flight muscle metabolic machinery early in life. Any further increases in flight metabolism with age or foraging experience are most likely achieved by operating metabolic enzymes closer to their maximal flux capacity.
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