ArticleDrug discovery today. Disease mechanisms2008
Modifying skin pigmentation - approaches through intrinsic biochemistry and exogenous agents.
Article in Drug discovery today. Disease mechanisms, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Safety and efficacy of niosomal and conventional tranexamic acid/niacinamide vs. hydroquinone creams in melasma: A randomized, double-blind, case-controlled clinical trial.Scientific reports · 2025Trial
- Non-invasive high-intensity focused ultrasound for UV-induced hyperpigmentation in Fitzpatrick skin types III and IV: a prospective, randomized, controlled, evaluator-blinded trial.Lasers in medical science · 2018Trial
- Targeting Melanin Production: The Safety of Tyrosinase Inhibition.International journal of molecular sciences · 2025Review
- The Role of Tyrosine Kinase in Beauty and Skincare: A Comprehensive Review.Journal of cosmetic dermatology · 2025Review
- Article
- Beneficial esthetic lightening effects ofJournal of family medicine and primary care · 2022Article
- Focus on the Contribution of Oxidative Stress in Skin Aging.Antioxidants (Basel, Switzerland) · 2022Review
- Revealing the genetic basis of eyelid pigmentation in Hereford cattle.Journal of animal science · 2022Article
- Sebocytes contribute to melasma onset.iScience · 2022Article
- Mitochondrial DNA-depleter mouse as a model to study human pigmentary skin disorders.Pigment cell & melanoma research · 2021Article
- Low-Temperature Argon Plasma Regulates Skin Moisturizing and Melanogenesis-Regulating Markers through Yes-Associated Protein.International journal of molecular sciences · 2021Article
- Laser-Assisted Depigmentation-An Introspection of the Science, Techniques, and Perceptions.Dentistry journal · 2020Review
- Dose response of black American mink to Aleutian mink disease virus.Immunity, inflammation and disease · 2020Article
- Assessment of the Pharmacological Properties and Phytochemical Profile ofBiomolecules · 2020Article
- Anti-melanin deposition activity and active constituents of Jatropha multifida stems.Journal of natural medicines · 2019Article
- Patient Preferences and Comparative Outcomes Regarding Cryosurgery versus Electrodesiccation in the Removal of Truncal Seborrheic Keratoses.The Journal of clinical and aesthetic dermatology · 2019Article
- Evaluating the Efficacy, Safety, and Tolerability of the Combination of Tazarotene, Azelaic Acid, Tacrolimus, and Zinc Oxide for the Treatment of Melasma: A Pilot Study.The Journal of clinical and aesthetic dermatology · 2019Article
- Myosin VI and branched actin filaments mediate membrane constriction and fission of melanosomal tubule carriers.The Journal of cell biology · 2018Article
- Efficacy of Conventional Laser Irradiation Versus a New Method for Gingival Depigmentation (Sieve Method): A Clinical Trial.Journal of lasers in medical sciences · 2017Article
- Skin Bleaching and Dermatologic Health of African and Afro-Caribbean Populations in the US: New Directions for Methodologically Rigorous, Multidisciplinary, and Culturally Sensitive Research.Dermatology and therapy · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Rates of skin cancer continue to increase despite the improved use of traditional sunscreens to minimize damage from ultraviolet radiation. The public perception of tanned skin as being healthy and desirable, combined with the rising demand for treatments to repair irregular skin pigmentation and the desire to increase or decrease constitutive skin pigmentation, arouses great interest pharmaceutically as well as cosmeceutically. This review discusses the intrinsic biochemistry of pigmentation, details mechanisms that lead to increased or decreased skin pigmentation, and summarizes established and potential hyper- and hypo-pigmenting agents and their modes of action.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.