ArticlePLoS genetics2009
Enhanced disease susceptibility 1 and salicylic acid act redundantly to regulate resistance gene-mediated signaling.
Article in PLoS genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed, 181 citations in OpenAlex.
- The AcWRKY40-AcICS1 Module Regulates Kiwifruit Resistance to Pseudomonas syringae pv. actinidiae via Salicylic Acid Synthesis.Plant, cell & environment · 2026Article
- Decoding plant defense signaling using the defenseless mutant.The New phytologist · 2026Article
- Contrasting Response of Santina and Bing Sweet Cherry Cultivars Under Combined Biotic and Abiotic Stress.Plants (Basel, Switzerland) · 2026Article
- Warm temperature suppresses plant systemic acquired resistance by intercepting N-hydroxypipecolic acid biosynthesis.The Plant journal : for cell and molecular biology · 2025Article
- Metabolomic Insights into Cross-Feeding Interactions Between Priestia megaterium PM and Pseudomonas fluorescens NO4: Unveiling Microbial Communication in Plant Growth-Promoting Rhizobacteria.Microbial ecology · 2025Article
- Genome Evolution of Two Intertidal Sargassum Species (S. fusiforme and S. thunbergii) and Their Response to Abiotic Stressors.Genome biology and evolution · 2025Article
- Co-evolution within the plant holobiont drives host performance.EMBO reports · 2023Review
- Transcription FactorInternational journal of molecular sciences · 2023Article
- Broader functions of TIR domains in Arabidopsis immunity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Plant Disease Resistance-Related Signaling Pathways: Recent Progress and Future Prospects.International journal of molecular sciences · 2022Review
- Genetic requirements for infection-specific responses in conferring disease resistance inFrontiers in plant science · 2022Article
- Comparative Transcriptome Analysis Reveals the Specific Activation of Defense Pathways AgainstFrontiers in plant science · 2022Article
- Symbiotic responses of Lotus japonicus to two isogenic lines of a mycorrhizal fungus differing in the presence/absence of an endobacterium.The Plant journal : for cell and molecular biology · 2021Article
- Two interacting transcriptional coactivators cooperatively control plant immune responses.Science advances · 2021Article
- Cotton GhSSI2 isoforms from the stearoyl acyl carrier protein fatty acid desaturase family regulate Verticillium wilt resistance.Molecular plant pathology · 2021Article
- Transcription FactorPlants (Basel, Switzerland) · 2021Article
- Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity.Nature communications · 2021Article
- Signals in systemic acquired resistance of plants against microbial pathogens.Molecular biology reports · 2021Review
- Review
- Volatile Compounds FromFrontiers in microbiology · 2021Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resistance (R) protein-associated pathways are well known to participate in defense against a variety of microbial pathogens. Salicylic acid (SA) and its associated proteinaceous signaling components, including enhanced disease susceptibility 1 (EDS1), non-race-specific disease resistance 1 (NDR1), phytoalexin deficient 4 (PAD4), senescence associated gene 101 (SAG101), and EDS5, have been identified as components of resistance derived from many R proteins. Here, we show that EDS1 and SA fulfill redundant functions in defense signaling mediated by R proteins, which were thought to function independent of EDS1 and/or SA. Simultaneous mutations in EDS1 and the SA-synthesizing enzyme SID2 compromised hypersensitive response and/or resistance mediated by R proteins that contain coiled coil domains at their N-terminal ends. Furthermore, the expression of R genes and the associated defense signaling induced in response to a reduction in the level of oleic acid were also suppressed by compromising SA biosynthesis in the eds1 mutant background. The functional redundancy with SA was specific to EDS1. Results presented here redefine our understanding of the roles of EDS1 and SA in plant defense.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.