ReviewDeutsches Arzteblatt international2009
The serological diagnosis of rheumatoid arthritis: antibodies to citrullinated antigens.
Review in Deutsches Arzteblatt international, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Antibodies against cyclic citrullinated peptides in infectious diseases--a systematic review.Clinical rheumatology · 2010Pooled it
- Nano-based Therapeutics for Rheumatoid Arthritis: Recent Patents and Development.Recent patents on nanotechnology · 2025Review
- Functional Analysis of Autoantibody Signatures in Rheumatoid Arthritis.Molecules (Basel, Switzerland) · 2022Article
- Human disease biomarker panels through systems biology.Biophysical reviews · 2021Review
- The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual "window of treatment success" in RA patients.Arthritis research & therapy · 2021Article
- Quality of life and its relation to periarticular bone changes in psoriatic patients with or without joint involvement.Clinical rheumatology · 2021Article
- Rheumatoid factor versus anti - cyclic citrullinated peptide antibody as screening tool for rheumatoid arthritis in an ophthalmic clinic.Indian journal of ophthalmology · 2020Article
- Polymorphisms inFrontiers in cellular and infection microbiology · 2018Article
- A set of conformationally well-defined L/D-peptide epitopes provides a serological bar code for autoantibody subtypes.PloS one · 2018Article
- A novel bedside test for ACPA: the CCPoint test is moving the laboratory to the rheumatologist's office.Immunologic research · 2017Article
- A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation.PloS one · 2016Article
- Mass cytometry as a platform for the discovery of cellular biomarkers to guide effective rheumatic disease therapy.Arthritis research & therapy · 2015Review
- The global challenges and opportunities in the practice of rheumatology: white paper by the World Forum on Rheumatic and Musculoskeletal Diseases.Clinical rheumatology · 2015Review
- Immunodiagnostic significance of anti-RA33 autoantibodies in Saudi patients with rheumatoid arthritis.Journal of immunology research · 2015Article
- Disease risk factors identified through shared genetic architecture and electronic medical records.Science translational medicine · 2014Article
- Personalized medicine using DNA biomarkers: a review.Human genetics · 2012Review
- Rheumatoid factor and antibodies against citrullinated peptides in Moroccan patients with rheumatoid arthritis: association with disease parameters and quality of life.Clinical rheumatology · 2012Article
- Association study of single nucleotide polymorphisms in pre-miRNA and rheumatoid arthritis in a Han Chinese population.Molecular biology reports · 2011Article
- [Therapeutic strategies in rheumatoid arthritis].Der Internist · 2011Article
- 62-year-old woman with fever, dyspnea, pleuritic chest pain, and weight loss.Mayo Clinic proceedings · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis article provides an overview of modern serological diagnostic testing for rheumatoid arthritis (RA) involving the detection of antibodies against citrullinated peptides/proteins (ACPA). Recommendations are also given for differential diagnosis and sequential testing in rheumatoid arthritis, with a view towards improving early diagnosis, so that irreparable joint damage can be avoided.
methodsSelective literature research, with consideration of the authors' own publications.
resultsTwo different, adequately evaluated testing systems, involving the detection of anti-CCP antibodies and of anti-MCV antibodies, are now commercially available and enable routine, relatively highly specific diagnostic testing for RA. Two point-of-care tests (POCT) for the early diagnosis of RA constitute the latest development in serologic diagnostic testing.
conclusionsThe two ACPA assays now on the market are equally useful for the diagnosis of rheumatoid arthritis. The correlation between RA disease activity and stratification with ACPA has only been demonstrated to date through the detection of anti-MCV antibodies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.