ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2009
Molecular typing of clinical adenovirus specimens by an algorithm which permits detection of adenovirus coinfections and intermediate adenovirus strains.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Community acquired respiratory virus infections in cancer patients-Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology.European journal of cancer (Oxford, England : 1990) · 2016Guideline
- High-incidence of human adenoviral co-infections in taiwan.PloS one · 2013Trial
- High-Frequency Recombination of Human Adenovirus in Children with Acute Respiratory Tract Infections in Beijing, China.Viruses · 2024Article
- SpeciesViruses · 2022Article
- Molecular Typing and Rapid Identification of Human Adenoviruses Associated With Respiratory Diseases Using Universal PCR and Sequencing Primers for the Three Major Capsid Genes: Penton Base, Hexon, and Fiber.Frontiers in microbiology · 2022Article
- Pseudo-outbreak of adenovirus in bronchoscopy suite.Infection control and hospital epidemiology · 2021Article
- Adenoviral Infections in Singapore: Should New Antiviral Therapies and Vaccines Be Adopted?The Journal of infectious diseases · 2020Article
- Virus detections among patients with severe acute respiratory illness, Northern Vietnam.PloS one · 2020Article
- Human adenovirus meningoencephalitis: a 3-years' overview.Journal of neurovirology · 2019Observational
- Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type D53 in an Eye Care Clinic - Los Angeles County, 2017.MMWR. Morbidity and mortality weekly report · 2018Article
- Adenovirus Type 21 Outbreak Among Lung Transplant Patients at a Large Tertiary Care Hospital.Open forum infectious diseases · 2018Article
- A multigene typing system for human adenoviruses reveals a new genotype in a collection of Swedish clinical isolates.PloS one · 2018Article
- Disseminated Adenovirus Infection After Combined Liver-Kidney Transplantation.Frontiers in cellular and infection microbiology · 2018Article
- Adenoviromics: Mining the Human Adenovirus Species D Genome.Frontiers in microbiology · 2018Review
- Quantitative real-time PCR assays for detection and type-specific identification of the endemic species C human adenoviruses.Journal of virological methods · 2016Article
- Molecular Epidemiology and Clinical Manifestations of Adenovirus Respiratory Infections in Taiwanese Children.Medicine · 2016Article
- Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012.BMC infectious diseases · 2015Article
- Respiratory Infections in the U.S. Military: Recent Experience and Control.Clinical microbiology reviews · 2015Review
- Adenovirus infections in immunocompetent and immunocompromised patients.Clinical microbiology reviews · 2014Review
- Broad-range PCR-electrospray ionization mass spectrometry for detection and typing of adenovirus and other opportunistic viruses in stem cell transplant patients.Journal of clinical microbiology · 2013Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundEpidemiological data suggest that clinical outcomes of human adenovirus (HAdV) infection may be influenced by virus serotype, coinfection with multiple strains, or infection with novel intermediate strains. In this report, we propose a clinical algorithm for detecting HAdV coinfection and intermediate strains. STUDY
designWe PCR amplified and sequenced subregions of the hexon and fiber genes of 342 HAdV-positive clinical specimens obtained from 14 surveillance laboratories. Sequences were then compared with those from 52 HAdV prototypic strains. HAdV-positive specimens that showed nucleotide sequence identity with a corresponding prototype strain were designated as being of that strain. When hexon and fiber gene sequences disagreed, or sequence identity was low, the specimens were further characterized by viral culture, plaque purification, repeat PCR with sequencing, and genome restriction enzyme digest analysis.
resultsOf the 342 HAdV-positive clinical specimens, 328 (95.9%) were single HAdV strain infections, 12 (3.5%) were coinfections, and 2 (0.6%) had intermediate strains. Coinfected specimens and intermediate HAdV strains considered together were more likely to be associated with severe illness compared to other HAdV-positive specimens (OR=3.8; 95% CI=1.2-11.9).
conclusionsThe majority of severe cases of HAdV illness cases occurred among immunocompromised patients. The analytic algorithm we describe here can be used to screen clinical specimens for evidence of HAdV coinfection and novel intermediate HAdV strains. This algorithm may be especially useful in investigating HAdV outbreaks and clusters of unusually severe HAdV disease.
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