ArticleThe Journal of surgical research2009
Outcomes of malignant CNS ependymomas: an examination of 2408 cases through the Surveillance, Epidemiology, and End Results (SEER) database (1973-2005).
Article in The Journal of surgical research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Clinical characteristics and prognostic factors of primary spinal subependymoma: a single-center cohort study and systematic review.Journal of neuro-oncology · 2025Pooled it
- CyberKnife for Recurrent Malignant Gliomas: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2021Pooled it
- Intraoperative MRI in pediatric brain tumor surgery: Optimizing surgical decision-making and extent of resection.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Observational
- Genomic and mutational landscape of anaplastic ependymoma: Insights from the AACR Project GENIE Consortium.Biomolecules & biomedicine · 2026Article
- Clinical Features and Prognostic Indicators for Brainstem Ependymomas : A Population-Based Retrospective Surveillance, Epidemiology, and End Results Database Analysis.Journal of Korean Neurosurgical Society · 2026Article
- Survival Patterns and Mortality Causes in Patients with Invasive Ependymoma: A Retrospective Cohort Analysis from 2000 to 2019.Medical sciences (Basel, Switzerland) · 2025Article
- Distinct relapse pattern across molecular ependymoma types.Neuro-oncology · 2025Article
- Optimizing outcomes in intracranial ependymoma: a contemporary review.Frontiers in oncology · 2025Review
- Disease characteristics and clinical specific survival prediction of spinal ependymoma: a genetic and population-based study.Frontiers in neurology · 2024Article
- Case report: Polymorphous low-grade neuroepithelial tumor of the young and supratentorial ependymoma diagnosed in an adult male.Frontiers in neurology · 2024Article
- Imaging of supratentorial ependymomas with radio-pathological correlation.Exploration of targeted anti-tumor therapy · 2024Article
- Adult intracranial ependymoma-relevance of DNA methylation profiling for diagnosis, prognosis, and treatment.Neuro-oncology · 2023Article
- The impact of 1.5-T intraoperative magnetic resonance imaging in pediatric tumor surgery: Safety, utility, and challenges.Frontiers in oncology · 2022Article
- Do We Need Radiotherapy in Grade II Ependymoma?Frontiers in oncology · 2022Article
- Treatment strategy for multisegmental cervicomedullary ependymoma: illustrative case.Journal of neurosurgery. Case lessons · 2021Article
- An Overview of Intracranial Ependymomas in Adults.Cancers · 2021Review
- Development and validation of prognostic nomogram in ependymoma: A retrospective analysis of the SEER database.Cancer medicine · 2021Article
- The role of sex genotype in paediatric CNS tumour incidence and survival.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Image-Guided Robotic Radiosurgery for the Management of Spinal Ependymomas.Frontiers in oncology · 2021Article
- Personalizing age-specific survival prediction and risk stratification in intracranial grade II/III ependymoma.Cancer medicine · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDetermine the role of surgery and radiation therapy for patients with malignant CNS ependymomas.
methodsThe Surveillance, Epidemiology, and End Results (SEER) database (1973-2005) was queried.
resultsOverall, a total of 2408 cases of malignant ependymomas were identified. Of these, 2132 cases (88.5%) were identified as WHO grade II ependymomas and 276 cases (11.5%) as WHO grade III (anaplastic) ependymomas. The annual incidence of ependymomas was approximately 1.97 cases per million in 2005. Overall median survival for all patients was 230 mo, with a significant difference between women and men (262 mo versus196 mo, respectively) (P=0.004). Median age at diagnosis was 37 y among females and 34 y in males. Patients who successfully underwent surgical resection had a considerably longer median survival (237 mo versus 215 mo, P<0.001) as well as a significantly improved five-year survival (72.4% versus 52.6%, P<0.001). Univariate analysis demonstrated that age, gender, ethnicity, primary tumor site, WHO grade and surgical resection were significant predictors of improved survival for ependymoma patients. Multivariate analysis identified that a WHO grade III tumor, male gender, patient age, intracranial tumor locations and failure to undergo surgical resection were independent predictors of poorer outcomes. Multivariate analysis of partially resection cases revealed that lack of radiation was a sign of poor prognosis (HR 1.748, P=0.024).
conclusionSurgical extirpation of ependymomas is associated with significantly improved patient survival. For partially resected tumors, radiation therapy provides significant survival benefit.
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