Evidence map›Paper›PMID 19577714›Full record

ReviewTrends in cardiovascular medicine2009

Sulfonylurea receptor 1 subunits of ATP-sensitive potassium channels and myocardial ischemia/reperfusion injury.

David J Lefer, Colin G Nichols, William A Coetzee

Abstract readReview
In one paragraph

Review in Trends in cardiovascular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Sevoflurane-mediated modulation of oxidative myocardial injury.Journal of cardiovascular and thoracic research · 2023
    Article
  5. Article
  6. Review
  7. Pharmacological modulation of mitochondrial ion channels.British journal of pharmacology · 2019
    Review
  8. Review
  9. Article
  10. Review
  11. KATP Channels in the Cardiovascular System.Physiological reviews · 2016
    Review
  12. Article
  13. Article
  14. Sulfonylurea receptor 1 expression in human cerebral infarcts.Journal of neuropathology and experimental neurology · 2013
    Article
  15. Redox control of cardiac excitability.Antioxidants & redox signaling · 2013
    Review
  16. Article
  17. Sulfonylurea receptor 1 in central nervous system injury: a focused review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012
    Review
  18. Review
  19. Article
  20. K(ATP) channels process nucleotide signals in muscle thermogenic response.Critical reviews in biochemistry and molecular biology · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David J LeferDepartment of Surgery, Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, GA, USA.
Colin G Nichols
William A Coetzee

Funding

SUR1 (ABCC8) AND ATRIAL KATP CHANNELSR01HL095010 · NHLBI · WASHINGTON UNIVERSITY · PI NICHOLS, COLIN G · 2009 to 2017
$3.4M
Potassium Channels as Macromolecular ComplexesR01HL085820 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COETZEE, WILLIAM A, NEUBERT, THOMAS A · 2008 to 2013
$3.2M
Cardioprotective Actions of Hydrogen SulfideR01HL092141 · NHLBI · LSU HEALTH SCIENCES CENTER · PI LEFER, DAVID JOSEPH · 2009 to 2013
$1.9M
Nitrite Mediated CardioprotectionR01HL093579 · NHLBI · LSU HEALTH SCIENCES CENTER · PI LEFER, DAVID JOSEPH · 2009 to 2012
$1.5M
MECHANISMS OF MYOCARDIAL REPERFUSION INJURY IN DIABETESR01HL060849 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI LEFER, DAVID JOSEPH · 1999 to 2008
$1.5M
NHLBI NIH HHS 1R01HL095010-01NHLBI NIH HHS 5R01HL085820-02NHLBI NIH HHS 7R01 HL060849-09NHLBI NIH HHS R01 HL060849NHLBI NIH HHS R01 HL085820NHLBI NIH HHS R01 HL092141NHLBI NIH HHS R01 HL093579NHLBI NIH HHS R01 HL095010
6 · The paper itself

Abstract

K(ATP) channels are generally cardioprotective under conditions of metabolic impairment, consisting of pore-forming (Kir6.1 and/or Kir6.2) and sulphonylurea-binding, modulatory subunits [sulfonylurea receptor (SUR) 1, 2A, or 2B]. Cardiovascular K(ATP) channels are generally thought to consist of Kir6.2/SUR2A subunits (in the case of heart muscle) or Kir6.1/SUR2B subunits (smooth muscle), whereas SUR1-containing channels have well-documented roles in pancreatic insulin release. Recent data, however, demonstrated the presence of SUR1 subunits in mouse cardiac tissue (particularly in atria) and a surprising protection from myocardial ischemia/reperfusion in SUR1-null mice. Here, we review some of the extra-pancreatic roles assigned to SUR1 subunits and consider whether these might be involved in the sequelae of ischemia/reperfusion.

Indexed as

AnimalsATP-Binding Cassette TransportersCoronary VesselsHeart AtriaHeart VentriclesHumansKATP ChannelsKcnj11 ChannelMiceMice, KnockoutMitochondria, HeartMyocardial Reperfusion InjuryMyocardiumPotassium Channels, Inwardly RectifyingReceptors, DrugSulfonylurea CompoundsABCC8 protein, humanAbcc8 protein, mouseABCC9 protein, humanAbcc9 protein, mouseATP-Binding Cassette TransportersKATP ChannelsKcnj11 ChannelPotassium Channels, Inwardly RectifyingReceptors, DrugSulfonylurea CompoundsSulfonylurea Receptors

Identifiers

PMID19577714
PMCPMC2706786

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.