ReviewTrends in cardiovascular medicine2009
The Carney complex gene PRKAR1A plays an essential role in cardiac development and myxomagenesis.
Review in Trends in cardiovascular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Article
- Arrhythmias are not to blame for all cardiac syncope patients: left atrial myxoma causing syncope in a middle-aged man.BMJ case reports · 2015Article
- Carney complex and McCune Albright syndrome: an overview of clinical manifestations and human molecular genetics.Molecular and cellular endocrinology · 2014Review
- PKA RIα homodimer structure reveals an intermolecular interface with implications for cooperative cAMP binding and Carney complex disease.Structure (London, England : 1993) · 2014Article
- Large atrial myxoma mimicking severe mitral stenosis associated with right heart enlargement and severe pulmonary hypertension.Cardiovascular diagnosis and therapy · 2013Article
- Cardiac masses, part 2: key imaging features for diagnosis and surgical planning.AJR. American journal of roentgenology · 2011Review
- Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the Carney complex gene Prkar1a.Molecular endocrinology (Baltimore, Md.) · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Cardiac myxomas are the most common primary tumors of the heart, although little is known about their etiology. Mutations of the protein kinase A regulatory subunit gene PRKAR1A cause inherited myxomas in the setting of the Carney complex tumor syndrome, providing a possible window for understanding their pathogenesis. We recently reported that cardiac-specific knockout of this gene causes myxomatous changes in the heart, although the mice die during gestation from cardiac failure. In this review, we discuss these findings and place them in the larger understanding of how protein kinase A dysregulation might affect cardiac function and cause myxomagenesis.
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