ReviewCurrent opinion in microbiology2009
Virus-host interactions: from systems biology to translational research.
Review in Current opinion in microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis reveals the commonalities and differences in Arabidopsis thaliana response to different viral pathogens.PloS one · 2012Pooled it
- HMGB1 is involved in viral replication and the inflammatory response in coxsackievirus A16-infected 16HBE cells via proteomic analysis and identification.Virology journal · 2023Article
- Tandem mass tag (TMT) labeling-based quantitative proteomic analysis reveals the cellular protein characteristics of 16HBE cells infected with coxsackievirus A10 and the potential effect of HMGB1 on viral replication.Archives of virology · 2023Article
- Article
- Article
- Protein Interactions Network of Porcine Circovirus Type 2 Capsid With Host Proteins.Frontiers in microbiology · 2020Article
- Protein Interactions Network of Hepatitis E Virus RNA and Polymerase With Host Proteins.Frontiers in microbiology · 2019Article
- Influenza-Omics and the Host Response: Recent Advances and Future Prospects.Pathogens (Basel, Switzerland) · 2017Review
- Prediction of GCRV virus-host protein interactome based on structural motif-domain interactions.BMC bioinformatics · 2017Article
- Systems Biology-Based Investigation of Cellular Antiviral Drug Targets Identified by Gene-Trap Insertional Mutagenesis.PLoS computational biology · 2016Article
- Biobanking and translation of human genetics and genomics for infectious diseases.Applied & translational genomics · 2014Article
- A comprehensive collection of systems biology data characterizing the host response to viral infection.Scientific data · 2014Article
- Quantitative modeling of virus evolutionary dynamics and adaptation in serial passages using empirically inferred fitness landscapes.Journal of virology · 2014Article
- Bugs in the system.Immunological reviews · 2013Review
- Unravelling the mechanisms of durable control of HIV-1.Nature reviews. Immunology · 2013Review
- Systems immunogenetics of vaccines.Seminars in immunology · 2013Review
- Kaposi's sarcoma: a computational approach through protein-protein interaction and gene regulatory networks analysis.Virus genes · 2013Article
- Genome-wide characterization of transcriptional patterns in high and low antibody responders to rubella vaccination.PloS one · 2013Article
- Discovery of cellular proteins required for the early steps of HCV infection using integrative genomics.PloS one · 2013Article
- Applying proteomic technology to clinical virology.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Research embracing systems biology approaches and careful analysis of the critical host response has greatly expanded our understanding of infectious diseases. First-generation studies based on genomics and proteomics have made significant progress in establishing the foundation for network-based investigations on virus-host interactions. More recently, data from complementary high-throughput technologies, such as siRNA and microRNA screens and next-generation sequencing, are augmenting systems level analyses and are providing a more detailed and insightful multidimensional view of virus-host networks. Together with advances in data integration, systems biology approaches now have the potential to provide profound impacts on translational research, leading to the more rapid development of new therapeutics and vaccines for infectious diseases. In this review, we highlight new high-throughput technologies, a new philosophy for studying virus-host interactions, and discuss the potential of systems biology to facilitate bench-to-bedside research and create novel strategies to combat disease. Can we save the world using these approaches? Read on.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.