Evidence map›Paper›PMID 19576778›Full record

ReviewTrends in microbiology2009

What we can learn about Escherichia coli through application of Gene Ontology.

James C Hu, Peter D Karp, Ingrid M Keseler, Markus Krummenacker, Deborah A Siegele

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. The EcoCyc database (2025).EcoSal Plus · 2025
    Review
  2. The EcoCyc Database (2023).EcoSal Plus · 2023
    Review
  3. Article
  4. The EcoCyc Database.EcoSal Plus · 2018
    Review
  5. The EcoCyc Database.EcoSal Plus · 2014
    Article
  6. Article
  7. EcoGene 3.0.Nucleic acids research · 2013
    Article
  8. Article
  9. Article
  10. The UniProt-GO Annotation database in 2011.Nucleic acids research · 2012
    Article
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

James C HuDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843-2128, USA. jimhu@tamu.edu
Peter D Karp
Ingrid M Keseler
Markus Krummenacker
Deborah A Siegele

Funding

The EcoCyc Model Organism Database for Escherichia coli [SRI Proposal ECU 14-631]U24GM077678 · NIGMS · SRI INTERNATIONAL · PI KARP, PETER D · 2006 to 2018
$12.3M
The EcoCyc Model Organism Database for Escherichia coliR01GM077678 · NIGMS · SRI INTERNATIONAL · PI KARP, PETER D · 2019 to 2022
$4.6M
Development of the www.EcoliCommunity.org Information ResourceU24GM077905 · NIGMS · PURDUE UNIVERSITY · PI WANNER, BARRY L · 2006 to 2009
$4.0M
NIGMS NIH HHS GM077678NIGMS NIH HHS R01 GM077678NIGMS NIH HHS U24 GM077678NIGMS NIH HHS U24 GM077905NIGMS NIH HHS U24GM077905
6 · The paper itself

Abstract

How we classify the genes, products and complexes that are present or absent in genomes, transcriptomes, proteomes and other datasets helps us place biological objects into subsystems with common functions, see how molecular functions are used to implement biological processes and compare the biology of different species and strains. Gene Ontology (GO) is one of the most successful systems for classifying biological function. Although GO is widely used for eukaryotic genomics, it has not yet been widely used for bacterial systems. The potential applications of GO are currently limited by the need to improve the annotation of bacterial genomes with GO and to improve how prokaryotic biology is represented in the ontology. Here, we discuss why GO should be adopted by microbiologists, and describe recent efforts to build and maintain high-quality GO annotation for Escherichia coli as a model system.

Indexed as

Computational BiologyEscherichia coliEscherichia coli ProteinsVocabulary, ControlledEscherichia coli Proteins

Identifiers

PMID19576778
PMCPMC3575750

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.