ArticleCurrent biology : CB2009
Reward motivation accelerates the onset of neural novelty signals in humans to 85 milliseconds.
Article in Current biology : CB, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Laminar activity in the hippocampus and entorhinal cortex related to novelty and episodic encoding.Nature communications · 2014Trial
- Crossmodal semantic congruence and rarity improve episodic memory.Memory & cognition · 2025Article
- Hippocampal convergence during anticipatory midbrain activation promotes subsequent memory formation.Nature communications · 2022Article
- Semantic Congruence Drives Long-Term Memory and Similarly Affects Neural Retrieval Dynamics in Young and Older Adults.Frontiers in aging neuroscience · 2021Article
- Dynamics of brain activity reveal a unitary recognition signal.Journal of experimental psychology. Learning, memory, and cognition · 2019Article
- Markers of Novelty Processing in Older Adults Are Stable and Reliable.Frontiers in aging neuroscience · 2019Article
- Individual differences in EEG correlates of recognition memory due to DAT polymorphisms.Brain and behavior · 2017Article
- Mutual Influence of Reward Anticipation and Emotion on Brain Activity during Memory Retrieval.Frontiers in psychology · 2017Article
- Finding and Not Finding Rat Perirhinal Neuronal Responses to Novelty.Hippocampus · 2016Article
- In search of a recognition memory engram.Neuroscience and biobehavioral reviews · 2015Review
- Fronto-limbic novelty processing in acute psychosis: disrupted relationship with memory performance and potential implications for delusions.Frontiers in behavioral neuroscience · 2015Article
- Novelty enhances visual salience independently of reward in the parietal lobe.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Pharmacological dissociation of novelty responses in the human brain.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Dopamine controls the neural dynamics of memory signals and retrieval accuracy.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Nucleus accumbens activity dissociates different forms of salience: evidence from human intracranial recordings.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Reward associations reduce behavioral interference by changing the temporal dynamics of conflict processing.PloS one · 2013Article
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- Contextual interaction between novelty and reward processing within the mesolimbic system.Human brain mapping · 2012Article
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- "Wanted!" the effects of reward on face recognition: electrophysiological correlates.Cognitive, affective & behavioral neuroscience · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The neural responses that distinguish novel from familiar items in recognition memory tasks are remarkably fast in both humans and nonhuman primates. In humans, the earliest onsets of neural novelty effects emerge at about approximately 150-200 ms after stimulus onset. However, in recognition memory studies with nonhuman primates, novelty effects can arise at as early as 70-80 ms. Here, we address the possibility that this large species difference in onset latencies is caused experimentally by the necessity of using reward reinforcement to motivate the detection of novel or familiar items in nonhuman primates but not in humans. Via magnetoencephalography in humans, we show in two experiments that the onset of neural novelty signals is accelerated from approximately 200 ms to approximately 85 ms if correct recognition memory for either novel or familiar items is rewarded. Importantly, this acceleration is independent of whether the detection of the novel or the familiar scenes is rewarded. Furthermore, this early novelty effect contributed to memory retrieval because neural reward responses, which were contingent upon novelty detection, followed approximately 100 ms later. Thus, under the contextual influence of reward motivation, behaviorally relevant novelty signals emerge much faster than previously held possible in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.