ArticleAmerican journal of human genetics2009
Genome-wide study of families with absolute pitch reveals linkage to 8q24.21 and locus heterogeneity.
Article in American journal of human genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Conceptual coherence but methodological mayhem: A systematic review of absolute pitch phenotyping.Behavior research methods · 2025Pooled it
- Absolute pitch exhibits phenotypic and genetic overlap with synesthesia.Human molecular genetics · 2013Trial
- Absolute pitch: effects of timbre on note-naming ability.PloS one · 2010Trial
- Brain structural morphometry in non-musicians with superior pitch identification ability.Scientific reports · 2026Article
- Assessing the relationship between absolute pitch and autistic traits using a novel continuous slider scale.BMC psychology · 2025Article
- Auditory temporal resolution and backward masking in musicians with absolute pitch.Frontiers in neuroscience · 2023Article
- Use of explicit priming to phenotype absolute pitch ability.PloS one · 2022Article
- Review
- The left dorsal stream causally mediates the tone labeling in absolute pitch.Annals of the New York Academy of Sciences · 2021Article
- Human Genomics and the Biocultural Origin of Music.International journal of molecular sciences · 2021Review
- Combination of absolute pitch and tone language experience enhances lexical tone perception.Scientific reports · 2021Article
- Revisiting discrete versus continuous models of human behavior: The case of absolute pitch.PloS one · 2020Article
- A Theory of Instrument-Specific Absolute Pitch.Frontiers in psychology · 2020Article
- Long-Term Musical Training Alters Auditory Cortical Activity to the Frequency Change.Frontiers in human neuroscience · 2020Article
- Article
- Perceptual Plasticity for Auditory Object Recognition.Frontiers in psychology · 2017Article
- Convergent evidence for the molecular basis of musical traits.Scientific reports · 2016Review
- Music Proficiency and Quantification of Absolute Pitch: A Large-Scale Study among Brazilian Musicians.Frontiers in neuroscience · 2016Article
- Article
- Top-Down Modulation on the Perception and Categorization of Identical Pitch Contours in Speech and Music.Frontiers in psychology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Absolute pitch (AP) is the rare ability to instantaneously recognize and label tones with their musical note names without using a reference pitch for comparison. The etiology of AP is complex. Prior studies have implicated both genetic and environmental factors in its genesis, yet the molecular basis for AP remains unknown. To locate regions of the human genome that may harbor AP-predisposing genetic variants, we performed a genome-wide linkage study on 73 multiplex AP families by genotyping them with 6090 SNP markers. Nonparametric multipoint linkage analyses were conducted, and the strongest evidence for linkage was observed on chromosome 8q24.21 in the subset of 45 families with European ancestry (exponential LOD score = 3.464, empirical genome-wide p = 0.03). Other regions with suggestive LOD scores included chromosomes 7q22.3, 8q21.11, and 9p21.3. Of these four regions, only the 7q22.3 linkage peak was also evident when 19 families with East Asian ancestry were analyzed separately. Though only one of these regions has yet reached statistical significance individually, we detected a larger number of independent linkage peaks than expected by chance overall, indicating that AP is genetically heterogeneous.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.