ArticleBrain research bulletin2009
Projections from auditory cortex to cholinergic cells in the midbrain tegmentum of guinea pigs.
Article in Brain research bulletin, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Characterization of three cholinergic inputs to the cochlear nucleus.Journal of chemical neuroanatomy · 2023Article
- The Neuromodulatory Role of the Noradrenergic and Cholinergic Systems and Their Interplay in Cognitive Functions: A Focused Review.Brain sciences · 2022Review
- A Signaled Locomotor Avoidance Action Is Fully Represented in the Neural Activity of the Midbrain Tegmentum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Multiple Sources of Cholinergic Input to the Superior Olivary Complex.Frontiers in neural circuits · 2021Article
- αFrontiers in neural circuits · 2021Article
- A Cortico-Collicular Amplification Mechanism for Gap Detection.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Article
- Cholinergic Projections From the Pedunculopontine Tegmental Nucleus Contact Excitatory and Inhibitory Neurons in the Inferior Colliculus.Frontiers in neural circuits · 2020Article
- The pedunclopontine nucleus and Parkinson's disease.Neurobiology of disease · 2019Review
- Thalamocortical and Intracortical Inputs Differentiate Layer-Specific Mouse Auditory Corticocollicular Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Functional Connectivity of the Pedunculopontine Nucleus and Surrounding Region in Parkinson's Disease.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Cholinergic Modulation of Stimulus-Specific Adaptation in the Inferior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The auditory corticocollicular system: molecular and circuit-level considerations.Hearing research · 2014Review
- Descending projections from auditory cortex to excitatory and inhibitory cells in the nucleus of the brachium of the inferior colliculus.Frontiers in systems neuroscience · 2014Article
- Axonal conduction block as a novel mechanism of prepulse inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Differentially organized top-down modulation of prepulse inhibition of startle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Cholinergic cells of the pontomesencephalic tegmentum: connections with auditory structures from cochlear nucleus to cortex.Hearing research · 2011Review
- Topographical organization of the pedunculopontine nucleus.Frontiers in neuroanatomy · 2011Article
- Projections from auditory cortex to midbrain cholinergic neurons that project to the inferior colliculus.Neuroscience · 2010Article
- Cholinergic and non-cholinergic projections from the pedunculopontine and laterodorsal tegmental nuclei to the medial geniculate body in Guinea pigs.Frontiers in neuroanatomy · 2010Article
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2 authors at 2 institutions in 1 country.
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Abstract
Anterograde and retrograde tracing techniques were used to characterize projections from the auditory cortex to the pedunculopontine and laterodorsal tegmental nuclei (PPT and LDT, respectively) in the midbrain tegmentum in guinea pigs. For anterograde tracing, tetramethylrhodamine dextran (FluoroRuby) was injected at several sites within auditory cortex. After sufficient time for transport, the brain was processed for immunohistochemistry with anti-choline acetyltransferase to reveal presumptive cholinergic cells. Anterogradely labeled axons were observed ipsilaterally and, in smaller numbers, contralaterally, in both the pedunculopontine and laterodorsal tegmental nuclei. In all four nuclei, tracer-labeled boutons appeared to contact immunolabeled (i.e., cholinergic) cells. The contacts occurred on cell bodies and dendrites. The results were similar following injections that spread across multiple auditory cortical areas or injections that were within primary auditory cortex. In order to confirm the anterograde results, in a second series of experiments, retrograde tracers were deposited in the pedunculopontine tegmental nucleus. These injections labeled layer V pyramidal cells in the auditory cortex. The results suggest an excitatory projection from primary auditory cortex bilaterally to cholinergic cells in the midbrain tegmentum. Such a pathway could allow auditory cortex to activate brainstem cholinergic circuits, possibly including the cholinergic pathways associated with arousal and gating of acoustic stimuli.
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