ArticleDevelopmental biology2009
Rap1 maintains adhesion between cells to affect Egfr signaling and planar cell polarity in Drosophila.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- The directionality of collective cell delamination is governed by tissue architecture and cell adhesion in aiScience · 2025Article
- Rap1 regulates apical contractility to allow embryonic morphogenesis without tissue disruption and acts in part via Canoe-independent mechanisms.Molecular biology of the cell · 2023Article
- Multivalent interactions make adherens junction-cytoskeletal linkage robust during morphogenesis.The Journal of cell biology · 2021Article
- An RNAi Screen for Genes Required for Growth ofG3 (Bethesda, Md.) · 2019Article
- TheMolecular biology of the cell · 2019Article
- Mbt/PAK4 together with SRC modulates N-Cadherin adherens junctions in the developingBiology open · 2019Article
- Article
- Rap1 GTPase promotes coordinated collective cell migration in vivo.Molecular biology of the cell · 2018Article
- Rap1, Canoe and Mbt cooperate with Bazooka to promote zonula adherens assembly in the fly photoreceptor.Journal of cell science · 2018Article
- Drosophila Condensin II subunit Chromosome-associated protein D3 regulates cell fate determination through non-cell-autonomous signaling.Development (Cambridge, England) · 2016Article
- The small GTPase Rap1 is a modulator of Hedgehog signaling.Developmental biology · 2016Article
- Apical accumulation of the Sevenless receptor tyrosine kinase during Drosophila eye development is promoted by the small GTPase Rap1.Genetics · 2014Article
- Discontinuities in Rap1 activity determine epithelial cell morphology within the developing wing of Drosophila.Developmental biology · 2012Article
- Atonal and EGFR signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.Development (Cambridge, England) · 2012Article
- The role of the small GTPase Rap in Drosophila R7 photoreceptor specification.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- The Rap1-Rgl-Ral signaling network regulates neuroblast cortical polarity and spindle orientation.The Journal of cell biology · 2011Article
- Morphometry and structure of natural random tilings.The European physical journal. E, Soft matter · 2010Article
- RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis.Blood · 2010Article
- Queen conch (Strombus gigas) testis regresses during the reproductive season at nearshore sites in the Florida Keys.PloS one · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The small GTPase Rap1 affects cell adhesion and cell motility in numerous developmental contexts. Loss of Rap1 in the Drosophila wing epithelium disrupts adherens junction localization, causing mutant cells to disperse, and dramatically alters epithelial cell shape. While the adhesive consequences of Rap1 inactivation have been well described in this system, the effects on cell signaling, cell fate specification, and tissue differentiation are not known. Here we demonstrate that Egfr-dependent cell types are lost from Rap1 mutant tissue as an indirect consequence of DE-cadherin mislocalization. Cells lacking Rap1 in the developing wing and eye are capable of responding to an Egfr signal, indicating that Rap1 is not required for Egfr/Ras/MAPK signal transduction. Instead, Rap1 regulates adhesive contacts necessary for maintenance of Egfr signaling between cells, and differentiation of wing veins and photoreceptors. Rap1 is also necessary for planar cell polarity in these tissues. Wing hair alignment and ommatidial rotation, functional readouts of planar cell polarity in the wing and eye respectively, are both affected in Rap1 mutant tissue. Finally, we show that Rap1 acts through the effector Canoe to regulate these developmental processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.