ArticleDevelopmental biology2009
The Ron receptor tyrosine kinase negatively regulates mammary gland branching morphogenesis.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- The Mammary Gland: Basic Structure and Molecular Signaling during Development.International journal of molecular sciences · 2022Review
- Article
- miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential.The Journal of experimental medicine · 2018Article
- DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.Cancer discovery · 2016Article
- Modulation of Mammary Gland Development and Milk Production by Growth Hormone Expression in GH Transgenic Goats.Frontiers in physiology · 2016Article
- HGFL supports mammary tumorigenesis by enhancing tumor cell intrinsic survival and influencing macrophage and T-cell responses.Oncotarget · 2015Article
- Vitamin D3-dependent VDR signaling delays ron-mediated breast tumorigenesis through suppression of β-catenin activity.Oncotarget · 2015Article
- Loss of vitamin D receptor signaling from the mammary epithelium or adipose tissue alters pubertal glandular development.American journal of physiology. Endocrinology and metabolism · 2014Article
- Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis.Mechanisms of development · 2014Article
- CD151 represses mammary gland development by maintaining the niches of progenitor cells.Cell cycle (Georgetown, Tex.) · 2014Article
- Ron receptor tyrosine kinase signaling as a therapeutic target.Expert opinion on therapeutic targets · 2012Review
- Conditional deletion of β-catenin in mammary epithelial cells of Ron receptor, Mst1r, overexpressing mice alters mammary tumorigenesis.Endocrinology · 2012Article
- Estrogen receptor alpha deletion enhances the metastatic phenotype of Ron overexpressing mammary tumors in mice.Molecular cancer · 2012Article
- Article
- Ron receptor deficient alveolar myeloid cells exacerbate LPS-induced acute lung injury in the murine lung.Innate immunity · 2011Article
- Article
- Integrated morphodynamic signalling of the mammary gland.Nature reviews. Molecular cell biology · 2011Review
- Chk2*1100delC Acts in synergy with the Ron receptor tyrosine kinase to accelerate mammary tumorigenesis in mice.Cancer letters · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The Ron receptor tyrosine kinase is expressed in normal breast tissue and is overexpressed in approximately 50% of human breast cancers. Despite the recent studies on Ron in breast cancer, nothing is known about the importance of this protein during breast development. To investigate the functional significance of Ron in the normal mammary gland, we compared mammary gland development in wild-type mice to mice containing a targeted ablation of the tyrosine kinase (TK) signaling domain of Ron (TK-/-). Mammary glands from RonTK-/- mice exhibited accelerated pubertal development including significantly increased ductal extension and branching morphogenesis. While circulating levels of estrogen, progesterone, and overall rates of epithelial cell turnover were unchanged, significant increases in phosphorylated MAPK, which predominantly localized to the epithelium, were associated with increased branching morphogenesis. Additionally, purified RonTK-/- epithelial cells cultured ex vivo exhibited enhanced branching morphogenesis, which was reduced upon MAPK inhibition. Microarray analysis of pubertal RonTK-/- glands revealed 393 genes temporally impacted by Ron expression with significant changes observed in signaling networks regulating development, morphogenesis, differentiation, cell motility, and adhesion. In total, these studies represent the first evidence of a role for the Ron receptor tyrosine kinase as a critical negative regulator of mammary development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.