ArticleDevelopmental biology2009
Expression of MafA in pancreatic progenitors is detrimental for pancreatic development.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Type 1 diabetes and engineering enhanced islet transplantation.Advanced drug delivery reviews · 2022Review
- Role of the Transcription Factor MAFA in the Maintenance of Pancreatic β-Cells.International journal of molecular sciences · 2022Review
- MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms.Biomolecules · 2022Review
- Alpha-to-beta cell trans-differentiation for treatment of diabetes.Biochemical Society transactions · 2021Review
- Article
- Notch signaling dynamically regulates adult β cell proliferation and maturity.The Journal of clinical investigation · 2019Article
- Improved insulin-secreting properties of pancreatic islet mesenchymal stem cells by constitutive expression of Pax4 and MafA.Turkish journal of biology = Turk biyoloji dergisi · 2017Article
- V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A Synthetic Modified mRNA Drives Reprogramming of Human Pancreatic Duct-Derived Cells Into Insulin-Secreting Cells.Stem cells translational medicine · 2016Article
- A synopsis of factors regulating beta cell development and beta cell mass.Cellular and molecular life sciences : CMLS · 2016Review
- A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells.Nature communications · 2016Article
- Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells.Diabetes · 2016Article
- Proper activation of MafA is required for optimal differentiation and maturation of pancreatic β-cells.Best practice & research. Clinical endocrinology & metabolism · 2015Review
- MafA is critical for maintenance of the mature beta cell phenotype in mice.Diabetologia · 2015Article
- Compensatory Response by Late Embryonic Tubular Epithelium to the Reduction in Pancreatic Progenitors.PloS one · 2015Article
- The temporal and hierarchical control of transcription factors-induced liver to pancreas transdifferentiation.PloS one · 2014Article
- Differentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA.Developmental biology · 2014Article
- A novel function of Onecut1 protein as a negative regulator of MafA gene expression.The Journal of biological chemistry · 2013Article
- Critical role of c-Kit in beta cell function: increased insulin secretion and protection against diabetes in a mouse model.Diabetologia · 2012Article
- β-cell-specific gene repression: a mechanism to protect against inappropriate or maladjusted insulin secretion?Diabetes · 2012Article
- Direct lineage conversions: unnatural but useful?Nature biotechnology · 2011Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The transcription factor MafA regulates glucose-responsive expression of insulin. MafA-deficient mice have a normal proportion of insulin+ cells at birth but develop diabetes gradually with age, suggesting that MafA is required for maturation and not specification of pancreatic beta-cells. However, several studies show that ectopic expression of MafA may have a role in specification as it induces insulin+ cells in chicken gut epithelium, reprograms adult murine acinar cells into insulin+ cells in combination with Ngn3 and Pdx1, and triggers the lens differentiation. Hence, we examined whether MafA can induce specification of beta-cells during pancreatic development. When the MafA transgene is expressed in Pdx1+ pancreatic progenitors, both pancreatic mass and proliferation of progenitors are reduced, at least partially due to induction of cyclin kinase inhibitors p27 and p57. Expression of MafA in Pdx1+ cells until E12.5 was sufficient to cause these effects and to disproportionately inhibit the formation of endocrine cells in the remnant pancreas. Thus, in mice, MafA expression in Pdx1+ pancreatic progenitors is not sufficient to specify insulin+ cells but in fact deters pancreatic development and the differentiation of endocrine cells. These findings imply that MafA should be used to enhance maturation, rather than specification, of beta-cells from stem/progenitor cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.