ArticleBMC genetics2009
Association between SNPs within candidate genes and compounds related to boar taint and reproduction.
Article in BMC genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 61 citations in OpenAlex.
- Effects ofFood science & nutrition · 2026Article
- Characterization of genomic diversity and population structure of worldwide Duroc subpopulations and other pig breeds.Genetics, selection, evolution : GSE · 2025Article
- Effect of SNPs in the Promoter Region on the Expression of Cytochrome P450 2E1 (CYP2E1) in Pig Liver.Animals : an open access journal from MDPI · 2024Article
- Population genetic analysis based on the polymorphisms mediated by transposons in the genomes of pig.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Endocrine Fertility Parameters-Genomic Background and their Genetic Relationship to Boar Taint in German Landrace and Large White.Animals : an open access journal from MDPI · 2021Article
- Characterization of Global DNA Methylation in Different Gene Regions Reveals Candidate Biomarkers in Pigs with High and Low Levels of Boar Taint.Veterinary sciences · 2020Article
- Genomic background and genetic relationships between boar taint and fertility traits in German Landrace and Large White.BMC genetics · 2020Article
- Characterization of Porcine Hepatic and Intestinal Drug Metabolizing CYP450: Comparison with Human Orthologues from A Quantitative, Activity and Selectivity Perspective.Scientific reports · 2019Article
- Systems genomics study reveals expression quantitative trait loci, regulator genes and pathways associated with boar taint in pigs.PloS one · 2018Article
- Exploiting whole genome sequence data to fine map and characterize candidate genes within a quantitative trait loci region affecting androstenone on porcine chromosome 5.Animal genetics · 2017Article
- Differential expression and co-expression gene networks reveal candidate biomarkers of boar taint in non-castrated pigs.Scientific reports · 2017Article
- Case-control approach application for finding a relationship between candidate genes and clinical mastitis in Holstein dairy cattle.Journal of applied genetics · 2016Article
- Efficiency of genomic prediction for boar taint reduction in Danish Landrace pigs.Animal genetics · 2015Article
- Identification of the novel candidate genes and variants in boar liver tissues with divergent skatole levels using RNA deep sequencing.PloS one · 2013Article
- Genome-wide association scan and phased haplotype construction for quantitative trait loci affecting boar taint in three pig breeds.BMC genomics · 2012Article
- Large scale genome-wide association and LDLA mapping study identifies QTLs for boar taint and related sex steroids.BMC genomics · 2011Article
- The distal end of porcine chromosome 6p is involved in the regulation of skatole levels in boars.BMC genetics · 2011Article
- Association of porcine heparanase and hyaluronidase 1 and 2 with reproductive and production traits in a landrace-duroc-yorkshire population.Frontiers in genetics · 2011Article
- A genome-wide association study on androstenone levels in pigs reveals a cluster of candidate genes on chromosome 6.BMC genetics · 2010Article
- Transcript profiling of candidate genes in testis of pigs exhibiting large differences in androstenone levels.BMC genetics · 2010Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoar taint is an unpleasant odour and flavour of the meat from some uncastrated male pigs primarily caused by elevated levels of androstenone and skatole in adipose tissue. Androstenone is produced in the same biochemical pathway as testosterone and estrogens, which represents a particular challenge when selecting against high levels of androstenone in the breeding programme, without simultaneously decreasing levels of other steroids. Detection of single nucleotide polymorphisms (SNPs) associated with compounds affecting boar taint is important both for gaining a better understanding of the complex regulation of the trait and for the purpose of identifying markers that can be used to improve the gain of breeding. The beneficial SNPs to be used in breeding would have the combinational effects of reducing levels of boar taint without affecting fertility of the animals. The aim of this study was to detect SNPs in boar taint candidate genes and to perform association studies for both single SNPs and haplotypes with levels of boar taint compounds and phenotypes related to reproduction.
resultsAn association study involving 275 SNPs in 121 genes and compounds related to boar taint and reproduction were carried out in Duroc and Norwegian Landrace boars. Phenotypes investigated were levels of androstenone, skatole and indole in adipose tissue, levels of androstenone, testosterone, estrone sulphate and 17beta-estradiol in plasma, and length of bulbo urethralis gland. The SNPs were genotyped in more than 2800 individuals and several SNPs were found to be significantly (LRT > 5.4) associated with the different phenotypes. Genes with significant SNPs in either of the traits investigated include cytochrome P450 members CYP2E1, CYP21, CYP2D6 and CYP2C49, steroid 5alpha-reductase SRD5A2, nuclear receptor NGFIB, catenin CTNND1, BRCA1 associated protein BAP1 and hyaluronoglucosaminidase HYAL2. Haplotype analysis provided additional evidence for an effect of CYP2E1 on levels of skatole and indole, and for BAP1, HYAL2 and SRD5A2 on levels of androstenone.
conclusionThe findings in this study indicate that polymorphisms in CYP2E1, CYP21, CYP2D6, CYP2C49, NGFIB and CTNND1 might be used to reduce levels of boar taint without affecting levels of testosterone, estrone sulphate, 17beta-estradiol or length of bulbo urethralis gland.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.