ReviewAnnual review of cell and developmental biology2009
The molecular basis of organ formation: insights from the C. elegans foregut.
Review in Annual review of cell and developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 60 citations in OpenAlex.
- Transcriptomic profiling of the embryonicbioRxiv : the preprint server for biology · 2026Article
- PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons inGenes & development · 2026Article
- PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons ofbioRxiv : the preprint server for biology · 2025Article
- Multi-tissue patterning drives anterior morphogenesis of the C. elegans embryo.Developmental biology · 2021Article
- Physically asymmetric division of theeLife · 2021Article
- Developmental Plasticity and Cellular Reprogramming inGenetics · 2019Review
- Distinct functions and temporal regulation of methylated histone H3 during early embryogenesis.Development (Cambridge, England) · 2019Article
- Reduction of mRNA export unmasks different tissue sensitivities to low mRNA levels during Caenorhabditis elegans development.PLoS genetics · 2019Article
- Specific Interactions Between Autosome andGenetics · 2019Article
- Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics.Mechanisms of ageing and development · 2019Review
- Temporal regulation of epithelium formation mediated by FoxA, MKLP1, MgcRacGAP, and PAR-6.Molecular biology of the cell · 2017Article
- A maternal-effect selfish genetic element inScience (New York, N.Y.) · 2017Article
- Caenorhabditis elegans as a model for understanding ROS function in physiology and disease.Redox biology · 2017Review
- Early Developmental Exposure to dsRNA Is Critical for Initiating Efficient Nuclear RNAi in C. elegans.Cell reports · 2017Article
- Morphogenesis of the C. elegans Intestine Involves Axon Guidance Genes.PLoS genetics · 2016Article
- Chlorophyll enhances oxidative stress tolerance in Caenorhabditis elegans and extends its lifespan.PeerJ · 2016Article
- TRANSCRIPTION. Recruitment of RNA polymerase II by the pioneer transcription factor PHA-4.Science (New York, N.Y.) · 2015Article
- Comparative RNA-Seq analysis reveals pervasive tissue-specific alternative polyadenylation in Caenorhabditis elegans intestine and muscles.BMC biology · 2015Article
- Forkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a.Intrinsically disordered proteins · 2015Review
- Analysis of PHA-1 reveals a limited role in pharyngeal development and novel functions in other tissues.Genetics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The digestive tracts of many animals are epithelial tubes with specialized compartments to break down food, remove wastes, combat infection, and signal nutrient availability. C. elegans possesses a linear, epithelial gut tube with foregut, midgut, and hindgut sections. The simple anatomy belies the developmental complexity that is involved in forming the gut from a pool of heterogeneous precursor cells. Here, I focus on the processes that specify cell fates and control morphogenesis within the embryonic foregut (pharynx) and the developmental roles of the pharynx after birth. Maternally donated factors in the pregastrula embryo converge on pha-4, a FoxA transcription factor that specifies organ identity for pharyngeal precursors. Positive feedback loops between PHA-4 and other transcription factors ensure commitment to pharyngeal fate. Binding-site affinity of PHA-4 for its target promoters contributes to the progression of the pharyngeal precursors towards differentiation. During morphogenesis, the pharyngeal precursors form an epithelial tube in a process that is independent of cadherins, catenins, and integrins but requires the kinesin zen-4/MKLP1. After birth, the pharynx and/or pha-4 are involved in repelling pathogens and controlling aging.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.