ArticleAnnual review of microbiology2009
Biological insights from structures of two-component proteins.
Article in Annual review of microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 452 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
452 citing papers in PubMed, 781 citations in OpenAlex.
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- Plant-Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two-Component System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Function and transcription of stoS gene of Xanthomonas campestris pathovar campestris.Antonie van Leeuwenhoek · 2026Article
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- Elucidating the mechanism of thiosulfate oxidation by a novel two-component system SulRS in deep-seaiScience · 2026Article
- Development of covalent inhibitors for bacterial histidine kinases.Chemical communications (Cambridge, England) · 2026Article
- Bacterial sensing and response for neutralization and detoxification of environmental ammonia.Journal of bacteriology · 2026Article
- Controllable protein design via autoregressive direct coupling analysis conditioned on principal components.PLoS computational biology · 2026Article
- QSProteome: a community-driven interactive platform for large-scale exploration and evaluation of predicted protein complex structures.Nucleic acids research · 2026Article
- Multiple input-multiple output (MIMO) designs in two-component signalling systems of Mycobacterium tuberculosis.FEMS microbiology reviews · 2026Review
- Co-evolution of RcsD and RcsF shapes signal transduction in the enterobacteriaceae Rcs system.PloS one · 2026Article
- A conserved residue in the histidine kinase BceS tunes bacitracin stress responses in Bacillus subtilis.Access microbiology · 2026Article
- AProceedings of the National Academy of Sciences of the United States of America · 2025Article
392 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Two-component signal transduction based on phosphotransfer from a histidine protein kinase to a response regulator protein is a prevalent strategy for coupling environmental stimuli to adaptive responses in bacteria. In both histidine kinases and response regulators, modular domains with conserved structures and biochemical activities adopt different conformational states in the presence of stimuli or upon phosphorylation, enabling a diverse array of regulatory mechanisms based on inhibitory and/or activating protein-protein interactions imparted by different domain arrangements. This review summarizes some of the recent structural work that has provided insight into the functioning of bacterial histidine kinases and response regulators. Particular emphasis is placed on identifying features that are expected to be conserved among different two-component proteins from those that are expected to differ, with the goal of defining the extent to which knowledge of previously characterized two-component proteins can be applied to newly discovered systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.