Evidence map›Paper›PMID 19575563›Full record

ReviewAnnual review of microbiology2009

Malaria parasite development in the mosquito and infection of the mammalian host.

Ahmed S I Aly, Ashley M Vaughan, Stefan H I Kappe

Abstract readReview
In one paragraph

Review in Annual review of microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

153 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. mBio · 2025
    Article
  8. Article
  9. Article
  10. Elevated NADNature communications · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. The possibilities and challenges associated with selective targetingTransactions of the Royal Society of South Africa. Royal Society of South Africa · 2025
    Article
  17. Review
  18. Review
  19. Article
  20. Article

93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ahmed S I AlySeattle Biomedical Research Institute, Seattle, Washington 98109, USA. stefan.kappe@sbri.org
Ashley M Vaughan
Stefan H I Kappe

Funding

New invasion-related proteins of Plasmodium sporozoitesR01AI053709 · NIAID · SEATTLE BIOMEDICAL RESEARCH INSTITUTE · PI KAPPE, STEFAN HI · 2003 to 2013
$3.5M
NIAID NIH HHS R01 AI053709
6 · The paper itself

Abstract

Plasmodium sporozoites are the product of a complex developmental process in the mosquito vector and are destined to infect the mammalian liver. Attention has been drawn to the mosquito stages and pre-erythrocytic stages owing to recognition that these are bottlenecks in the parasite life cycle and that intervention at these stages can block transmission and prevent infection. Parasite progression in the Anopheles mosquito, sporozoite transmission to the mammalian host by mosquito bite, and subsequent infection of the liver are characterized by extensive migration of invasive stages, cell invasion, and developmental changes. Preparation for the liver phase in the mammalian host begins in the mosquito with an extensive reprogramming of the sporozoite to support efficient infection and survival. Here, we discuss what is known about the molecular and cellular basis of the developmental progression of parasites and their interactions with host tissues in the mosquito and during the early phase of mammalian infection.

Indexed as

AnimalsAnophelesHumansMalariaPlasmodium

Identifiers

PMID19575563
PMCPMC2841446

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.