ArticleStatistics in medicine2009
Developing multicomponent interventions using fractional factorial designs.
Article in Statistics in medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06057324 (Switching Mediterranean Consumers to Mediterranean Sustainable Healthy Dietary Patterns by Combining Digital Interactive Tools with Targeted Educational Material and Sustainable Snacks), which is not on this map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Switching Mediterranean Consumers to Mediterranean Sustainable Healthy Dietary Patterns by Combining Digital Interactive Tools with Targeted Educational Material and Sustainable Snacks
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of social media in reducing risk factors for noncommunicable diseases: a systematic review and meta-analysis of randomized controlled trials.Nutrition reviews · 2016Pooled it
- Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial.JAMA network open · 2023Trial
- A randomised fractional factorial screening experiment to predict effective features of audit and feedback.Implementation science : IS · 2022Trial
- Efficacy of Contextually Tailored Suggestions for Physical Activity: A Micro-randomized Optimization Trial of HeartSteps.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019Trial
- Optimising text messaging to improve adherence to web-based smoking cessation treatment: a randomised control trial protocol.BMJ open · 2016Trial
- Evaluating the QUIT-PRIMO clinical practice ePortal to increase smoker engagement with online cessation interventions: a national hybrid type 2 implementation study.Implementation science : IS · 2015Trial
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- Feasibility and Acceptability of a Positive Psychological Intervention for Patients With Metastatic Breast Cancer: Pre-Post Pilot Study.JMIR formative research · 2025Article
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- Design of experiments with sequential randomizations on multiple timescales: the hybrid experimental design.Behavior research methods · 2024Article
- Evaluation of randomized controlled trials: a primer and tutorial for mental health researchers.Trials · 2023Article
- Co-designing a Canadian adaptation of a lifestyle-oriented intervention aimed to improve daily functioning of individuals living with chronic pain: a multi-method study protocol of REVEAL(OT) Canada.Frontiers in rehabilitation sciences · 2023Article
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- A randomized iterative approach to optimizing an online substance use intervention for collegiate athletes.Translational behavioral medicine · 2022Article
- Behavioral Interventions in Mild Cognitive Impairment (MCI): Lessons from a Multicomponent Program.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- MCMTC: A Pragmatic Framework for Selecting an Experimental Design to Inform the Development of Digital Interventions.Frontiers in digital health · 2022Article
- Barriers to Building More Effective Treatments: Negative Interactions Amongst Smoking Intervention Components.Clinical psychological science : a journal of the Association for Psychological Science · 2021Article
- Digital Therapeutics for Obesity and Eating-Related Problems.Endocrinology and metabolism (Seoul, Korea) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Multicomponent interventions composed of behavioral, delivery, or implementation factors in addition to medications are becoming increasingly common in health sciences. A natural experimental approach to developing and refining such multicomponent interventions is to start with a large number of potential components and screen out the least active ones. Factorial designs can be used efficiently in this endeavor. We address common criticisms and misconceptions regarding the use of factorial designs in these screening studies. We also provide an operationalization of screening studies. As an example, we consider the use of a screening study in the development of a multicomponent smoking cessation intervention. Simulation results are provided to support the discussions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.