ArticleStem cells (Dayton, Ohio)2009
Mature adult dystrophic mouse muscle environment does not impede efficient engrafted satellite cell regeneration and self-renewal.
Article in Stem cells (Dayton, Ohio), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Preservation of satellite cell number and regenerative potential with age reveals locomotory muscle bias.Skeletal muscle · 2021Article
- Irradiation dependent inflammatory response may enhance satellite cell engraftment.Scientific reports · 2020Article
- Restoration of Functional Full-Length Dystrophin After Intramuscular Transplantation of Foamy Virus-Transduced Myoblasts.Human gene therapy · 2020Article
- Impaired Regeneration in Dystrophic Muscle-New Target for Therapy.Frontiers in molecular neuroscience · 2020Article
- Visualization of PAX7 protein dynamics in muscle satellite cells in a YFP knock-in-mouse line.Skeletal muscle · 2018Article
- The effect of calorie restriction on mouse skeletal muscle is sex, strain and time-dependent.Scientific reports · 2017Article
- Article
- Identification and Characterization of the Dermal Panniculus Carnosus Muscle Stem Cells.Stem cell reports · 2016Article
- Stem cell activation in skeletal muscle regeneration.Cellular and molecular life sciences : CMLS · 2015Review
- Satellite cells from dystrophic muscle retain regenerative capacity.Stem cell research · 2015Article
- Early forming label-retaining muscle stem cells require p27kip1 for maintenance of the primitive state.Development (Cambridge, England) · 2014Article
- Emerging gene editing strategies for Duchenne muscular dystrophy targeting stem cells.Frontiers in physiology · 2014Review
- Recent progress in satellite cell/myoblast engraftment -- relevance for therapy.The FEBS journal · 2013Review
- Article
- Fetal microchimeric cells in a fetus-treats-its-mother paradigm do not contribute to dystrophin production in serially parous mdx females.Stem cells and development · 2012Article
- Defects in glycosylation impair satellite stem cell function and niche composition in the muscles of the dystrophic Large(myd) mouse.Stem cells (Dayton, Ohio) · 2012Article
- Donor satellite cell engraftment is significantly augmented when the host niche is preserved and endogenous satellite cells are incapacitated.Stem cells (Dayton, Ohio) · 2012Article
- Human satellite cells: identification on human muscle fibres.PLoS currents · 2012Article
- The satellite cell in male and female, developing and adult mouse muscle: distinct stem cells for growth and regeneration.PloS one · 2012Article
- Assessment of the myogenic stem cell compartment following transplantation of Pax3/Pax7-induced embryonic stem cell-derived progenitors.Stem cells (Dayton, Ohio) · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Changes that occur in the skeletal muscle environment with the progress of muscular dystrophies may affect stem cell function and result in impaired muscle regeneration. It has previously been suggested that the success of stem cell transplantation could therefore be dependent both on the properties of the cell itself and on the host muscle environment. Here we engrafted young and mature adult mdx-nude mice, which are the genetic homolog of Duchenne muscular dystrophy, with a small number of satellite cells freshly isolated from young, normal donor mice. We found that the donor satellite cells contributed to muscle regeneration and self-renewal as efficiently within mature adult, as in young, dystrophic host muscle. Donor-derived satellite cells also contributed to robust regeneration after further injury, showing that they were functional despite the more advanced dystrophic muscle environment. These findings provide evidence that muscle tissue in a later stage of dystrophy may be effectively treated by stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.