Trial reportObesity surgery2009
Improvement in glycemic control in morbidly obese type 2 diabetic subjects by gastric stimulation.
Trial report in Obesity surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Association of Gastric Myoelectrical Activity With Ghrelin, Gastrin, and Irisin in Adults With Metabolically Healthy and Unhealthy Obesity.Frontiers in physiology · 2022Article
- The Role of Minimally Invasive and Endoscopic Technologies in Morbid Obesity Treatment: Review and Critical Appraisal of the Current Clinical Practice.Obesity surgery · 2020Review
- Use of Bioelectronics in the Gastrointestinal Tract.Cold Spring Harbor perspectives in medicine · 2019Review
- Neurostimulation of the gastrointestinal tract: review of recent developments.Neuromodulation : journal of the International Neuromodulation Society · 2015Review
- The DIAMOND system in the treatment of type 2 diabetes mellitus in an obese patient.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2014Article
- Updates on gastric electrical stimulation to treat obesity: Systematic review and future perspectives.World journal of gastrointestinal endoscopy · 2014Article
- Interventional diabetology: the evolution of diabetes care in the XXI century.Current atherosclerosis reports · 2012Review
- Gastric stimulation in the digestive period modifies length and contractility of the inter-digestive period in obese non-diabetic and diabetic subjects.Obesity surgery · 2012Article
- Gastric stimulation for weight loss.World journal of gastroenterology · 2012Review
- Diabetic and bariatric surgery: a review of the recent trends.Surgical endoscopy · 2012Review
- [Indications and principles of metabolic surgery].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastric electrical stimulation synchronized to the refractory period of gastric electrical activity and applied during meals was evaluated for safety and for improvement of body weight and glycemic control in obese type 2 diabetes.
methodsThe study involved obese diabetic type 2 (ODM) patients in a multicenter open-label European feasibility trial. A total of 24 ODM (nine males, 15 females) treated with insulin and/or oral hyperglycemic agents and body mass index between 33.3 to 49.7 kg/m(2) were implanted laparoscopically with a TANTALUS system.
resultsThere were 18 adverse events related to the implant procedure or the device reported in 12 subjects. All were short lived and resolved with no sequelae. In the 21 subjects that reached the 1-year visit weight was reduced by 4.5 +/- 2.7 kg (p < 0.05) and HbA1c by 0.5 +/- 0.3% (p < 0.05). In a subgroup (n = 11) on stable or reduced oral medication, weight was reduced by 6.3 +/- 3.4 kg (p < 0.05) and HbA1c by 0.9 +/- 0.4% (p < 0.05). The group on insulin (n = 6) had no significant changes in weight and HbA1c.
conclusionsThe TANTALUS system is well tolerated in obese type 2 diabetic subjects. Gastric electrical stimulation can potentially improve glucose metabolism and induce weight loss in obese diabetic patients, who are not well controlled on oral antidiabetic therapy. Further evaluation is required to determine whether this effect is due to induced weight loss and/or to direct signal dependent mechanisms.
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Registered trials
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