ArticleJournal of neuro-oncology2010
[11C]-L-methionine positron emission tomography in the management of children and young adults with brain tumors.
Article in Journal of neuro-oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- A meta-analysis on the diagnostic performance of (18)F-FDG and (11)C-methionine PET for differentiating brain tumors.AJNR. American journal of neuroradiology · 2014Pooled it
- Characterization of intracranial space-occupying lesions by ⁹⁹(m)Tc-Tetrofosmin SPECT.Journal of neuro-oncology · 2011Trial
- Clinical Utility of Amino Acid PET-MRI in Children with CNS Neoplasms: A Territory-Wide Study from Hong Kong.Cancers · 2025Article
- Joint EANM/SIOPE/RAPNO practice guidelines/SNMMI procedure standards for imaging of paediatric gliomas using PET with radiolabelled amino acids and [European journal of nuclear medicine and molecular imaging · 2022Article
- Diagnostic accuracy and clinical impact of [18F]FET PET in childhood CNS tumors.Neuro-oncology · 2021Article
- Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Visual and semiquantitative 11C-methionine PET: an independent prognostic factor for survival of newly diagnosed and treatment-naïve gliomas.Neuro-oncology · 2018Article
- Prognostic value of molecular and imaging biomarkers in patients with supratentorial glioma.European journal of nuclear medicine and molecular imaging · 2017Article
- Structural Snapshots of an Engineered Cystathionine-γ-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.Biochemistry · 2017Article
- Nuclear Medicine Imaging in Pediatric Neurology.Molecular imaging and radionuclide therapy · 2016Article
- Utility ofAmerican journal of nuclear medicine and molecular imaging · 2016Article
- Prognostic Value of Metabolic Tumor Volume on (11)C-Methionine PET in Predicting Progression-Free Survival in High-Grade Glioma.Nuclear medicine and molecular imaging · 2015Article
- Oligodendroglial component complicates the prediction of tumour grading with metabolic imaging.European journal of nuclear medicine and molecular imaging · 2015Article
- (18)F-FET-PET guided surgical biopsy and resection in children and adolescence with brain tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Article
- 2-deoxy-2-((18)F)fluoro-D-glucose positron emission tomography/computed tomography imaging in paediatric oncology.World journal of radiology · 2014Review
- Accuracy of distinguishing between dysembryoplastic neuroepithelial tumors and other epileptogenic brain neoplasms with [¹¹C]methionine PET.Neuro-oncology · 2014Article
- Progress on the diagnosis and evaluation of brain tumors.Cancer imaging : the official publication of the International Cancer Imaging Society · 2013Review
- Value of 11C-methionine PET in imaging brain tumours and metastases.European journal of nuclear medicine and molecular imaging · 2013Review
- Evaluation of brain tumors using dynamic 11C-methionine-PET.Journal of neuro-oncology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Only a few Methyl-[11C]-L-methionine (MET) positron emission tomography (PET) studies have focused on children and young adults with brain neoplasm. Due to radiation exposure, long scan acquisition time, and the need for sedation in young children MET-PET studies should be restricted to this group of patients when a decision for further therapy is not possible from routine diagnostic procedures alone, e.g., structural imaging. We investigated the diagnostic accuracy of MET-PET for the differentiation between tumorous and non-tumorous lesions in this group of patients. Forty eight MET-PET scans from 39 patients aged from 2 to 21 years (mean 15 +/- 5.0 years) were analyzed. The MET tumor-uptake relative to a corresponding control region was calculated. A receiver operating characteristic (ROC) was performed to determine the MET-uptake value that best distinguishes tumorous from non-tumorous brain lesions. A differentiation between tumorous (n = 39) and non-tumorous brain lesions (n = 9) was possible at a threshold of 1.48 of relative MET-uptake with a sensitivity of 83% and a specificity of 92%, respectively. A differentiation between high grade malignant lesions (mean MET-uptake = 2.00 +/- 0.46) and low grade tumors (mean MET-uptake = 1.84 +/- 0.31) was not possible. There was a significant difference in MET-uptake between the histologically homogeneous subgroups of astrocytoma WHO grade II and anaplastic astrocytoma WHO grade III (P = 0.02). MET-PET might be a useful tool to differentiate tumorous from non-tumorous lesions in children and young adults when a decision for further therapy is difficult or impossible from routine structural imaging procedures alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.