ArticleJournal of applied physiology (Bethesda, Md. : 1985)2009
Hormone therapy attenuates exercise-induced skeletal muscle damage in postmenopausal women.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 52 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed, 3 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Evaluation of curcumin intake in reducing exercise-induced muscle damage in athletes: a systematic review.Journal of the International Society of Sports Nutrition · 2024Pooled it
- Attenuating Muscle Damage Biomarkers and Muscle Soreness After an Exercise-Induced Muscle Damage with Branched-Chain Amino Acid (BCAA) Supplementation: A Systematic Review and Meta-analysis with Meta-regression.Sports medicine - open · 2024Pooled it
- Pooled it
- Short-term creatine supplementation enhances strength, reduces fatigue, and accelerates recovery in resistance-trained athletes: a double-blind, randomized, crossover trial.Journal of the International Society of Sports Nutrition · 2025Trial
- Effects of transdermal estrogen therapy on satellite cell number and molecular markers for muscle hypertrophy in response to resistance training in early postmenopausal women.European journal of applied physiology · 2023Trial
- Effect of eccentric and concentric contraction mode on myogenic regulatory factors expression in human vastus lateralis muscle.Journal of muscle research and cell motility · 2022Trial
- Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS).European journal of applied physiology · 2015Trial
- Avenanthramide supplementation attenuates exercise-induced inflammation in postmenopausal women.Nutrition journal · 2014Trial
- Influence of oestradiol on exercise induced muscular damage and heart rate variability in a non-trained healthy population.Experimental physiology · 2026Article
- Robust immune cell infiltration and macrophage senescence occur within a week of recovery after limb immobilization in older adult skeletal muscle.The Journal of physiology · 2026Article
- Estrogen in skeletal muscle: metabolism, mechanisms, and exercise-induced changes.Journal of endocrinological investigation · 2026Review
- Sexual dimorphisms in skeletal muscle: current concepts and research horizons.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Review
- Effect of Eccentric Exercise on Metabolic Health in Diabetes and Obesity.Sports medicine - open · 2023Review
- Recovery from Resistance Exercise in Older Adults: A Systematic Scoping Review.Sports medicine - open · 2023Article
- Mechanisms of Estrogen Influence on Skeletal Muscle: Mass, Regeneration, and Mitochondrial Function.Sports medicine (Auckland, N.Z.) · 2022Review
- Considerations for Sex-Cognizant Research in Exercise Biology and Medicine.Frontiers in sports and active living · 2022Review
- Sex Hormones and Satellite Cell Regulation in Women.Translational sports medicine · 2022Review
- Sex-Based Differences in the Myogenic Response and Inflammatory Gene Expression Following Eccentric Contractions in Humans.Frontiers in physiology · 2022Article
- Sex differences in the impact of resistance exercise load on muscle damage: A protocol for a randomised parallel group trial.PloS one · 2022Article
- Sex-dependent membranopathy in stored human red blood cells.Haematologica · 2021Article
Corrections and comments
- Erratum issuedSattler, F R [added]
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Hormone therapy (HT) is a potential treatment to relieve symptoms of menopause and prevent the onset of disease such as osteoporosis in postmenopausal women. We evaluated changes in markers of exercise-induced skeletal muscle damage and inflammation [serum creatine kinase (CK), serum lactate dehydrogenase (LDH), and skeletal muscle mRNA expression of IL-6, IL-8, IL-15, and TNF-alpha] in postmenopausal women after a high-intensity resistance exercise bout. Fourteen postmenopausal women were divided into two groups: women not using HT (control; n = 6, 59 +/- 4 yr, 63 +/- 17 kg) and women using traditional HT (HT; n = 8, 59 +/- 4 yr, 89 +/- 24 kg). Both groups performed 10 sets of 10 maximal eccentric repetitions of single-leg extension on the Cybex dynamometer at 60 degrees /s with 20-s rest periods between sets. Muscle biopsies of the vastus lateralis were obtained from the exercised leg at baseline and 4 h after the exercise bout. Gene expression was determined by RT-PCR for IL-6, IL-8, IL-15, and TNF-alpha. Blood draws were performed at baseline and 3 days after exercise to measure CK and LDH. Independent t-tests were performed to test group differences (control vs. HT). A probability level of P <or= 0.05 was used to determine statistical significance. We observed significantly greater changes in mRNA expression of IL-6, IL-8, IL-15, and TNF-alpha (P <or= 0.01) in the control group compared with the HT group after the exercise bout. CK and LDH levels were significantly greater after exercise (P <or= 0.01) in the control group. Postmenopausal women not using HT experienced greater muscle damage after maximal eccentric exercise, indicating a possible protective effect of HT against exercise-induced skeletal muscle damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.