ArticleBrain : a journal of neurology2009
Age and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact.
Article in Brain : a journal of neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Pooled it
- Bulk and single-cell RNA-seq analyses characterize a DBP-related circadian signature in ischemic stroke.iScience · 2026Article
- Microglial DBP Signaling Mediates Behavioral Abnormality Induced by Chronic Periodontitis in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Vitamin D binding protein in psychiatric and neurological disorders: Implications for diagnosis and treatment.Genes & diseases · 2024Review
- Elucidating the changes in the heterogeneity and function of radiation-induced cardiac macrophages using single-cell RNA sequencing.Frontiers in immunology · 2024Article
- Plasma Levels of Tissue-Type Plasminogen Activator (tPA) in Normal Aging and Alzheimer's Disease: Links With Cognition, Brain Structure, Brain Function and Amyloid Burden.Frontiers in aging neuroscience · 2022Article
- TNF-α antagonism rescues the effect of ageing on stroke: Perspectives for targeting inflamm-ageing.European journal of clinical investigation · 2021Article
- The impact of sex and age on T cell immunity and ischemic stroke outcomes.Cellular immunology · 2019Review
- The role of transcriptional factor D-site-binding protein in circadian CCL2 gene expression in anti-Thy1 nephritis.Cellular & molecular immunology · 2019Article
- Deficiency of tPA Exacerbates White Matter Damage, Neuroinflammation, Glymphatic Dysfunction and Cognitive Dysfunction in Aging Mice.Aging and disease · 2019Article
- Sub-acute systemic erythropoietin administration reduces ischemic brain injury in an age-dependent manner.Oncotarget · 2016Article
- Normalization of Reverse Transcription Quantitative PCR Data During Ageing in Distinct Cerebral Structures.Molecular neurobiology · 2016Article
- Stressed neurons protect themselves by a tissue-type plasminogen activator-mediated EGFR-dependent mechanism.Cell death and differentiation · 2016Article
- Impacts of tissue-type plasminogen activator (tPA) on neuronal survival.Frontiers in cellular neuroscience · 2015Review
- Plasmin-dependent modulation of the blood-brain barrier: a major consideration during tPA-induced thrombolysis?Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Review
- Perfusion of ischemic brain in young and aged animals: a laser speckle flowmetry study.Stroke · 2014Article
- Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB.Human molecular genetics · 2013Article
- Article
- Impact of tissue plasminogen activator on the neurovascular unit: from clinical data to experimental evidence.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2011Review
- Tissue plasminogen activator prevents white matter damage following stroke.The Journal of experimental medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 7 institutions in 3 countries.
Funding
Abstract
Recombinant tissue-type plasminogen activator (tPA) is the fibrinolytic drug of choice to treat stroke patients. However, a growing body of evidence indicates that besides its beneficial thrombolytic role, tPA can also have a deleterious effect on the ischaemic brain. Although ageing influences stroke incidence, complications and outcome, age-dependent relationships between endogenous tPA and stroke injuries have not been investigated yet. Here, we report that ageing is associated with a selective lowering of brain tPA expression in the murine brain. Moreover, our results show that albumin D site-binding protein (DBP) as a key age-associated regulator of the neuronal transcription of tPA. Additionally, inhibition of DBP-mediated tPA expression confers in vitro neuroprotection. Accordingly, reduced levels of tPA in old mice are associated with smaller excitotoxic/ischaemic injuries and protection of the permeability of the neurovascular unit during cerebral ischaemia. Likewise, we provide neuroradiological evidence indicating the existence of an inverse relationship between age and the volume of the ischaemic lesion in patients with acute ischaemic stroke. Together, these results indicate that the relationship among DBP, tPA and ageing play an important role in the outcome of cerebral ischaemia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.