ArticleThe Journal of biological chemistry2009
Drosomycin, an innate immunity peptide of Drosophila melanogaster, interacts with the fly voltage-gated sodium channel.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
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- Article
- Mutation-driven evolution of antibacterial function in an ancestral antifungal scaffold: Significance for peptide engineering.Frontiers in microbiology · 2022Article
- Evolution-Based Protein Engineering for Antifungal Peptide Improvement.Molecular biology and evolution · 2021Article
- Membrane-Interacting Antifungal Peptides.Frontiers in cell and developmental biology · 2021Review
- Bioactive Peptides Against Fungal Biofilms.Frontiers in microbiology · 2019Review
- Immune-cognitive system connectivity reduces bumblebee foraging success in complex multisensory floral environments.Scientific reports · 2018Article
- Article
- Antifungal Activity against Filamentous Fungi of Ts1, a Multifunctional Toxin fromFrontiers in microbiology · 2017Article
- Age and Diet Affect Genetically Separable Secondary Injuries that Cause Acute Mortality Following Traumatic Brain Injury in Drosophila.G3 (Bethesda, Md.) · 2016Article
- The drosomycin multigene family: three-disulfide variants from Drosophila takahashii possess antibacterial activity.Scientific reports · 2016Article
- Dnr1 mutations cause neurodegeneration in Drosophila by activating the innate immune response in the brain.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Antifungal proteins: More than antimicrobials?Fungal biology reviews · 2013Article
- Juruin: an antifungal peptide from the venom of the Amazonian Pink Toe spider, Avicularia juruensis, which contains the inhibitory cystine knot motif.Frontiers in microbiology · 2012Article
- Peptide-based Antifungal Therapies against Emerging Infections.Drugs of the future · 2010Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several peptide families, including insect antimicrobial peptides, plant protease inhibitors, and ion channel gating modifiers, as well as blockers from scorpions, bear a common CSalphabeta scaffold. The high structural similarity between two peptides containing this scaffold, drosomycin and a truncated scorpion beta-toxin, has prompted us to examine and compare their biological effects. Drosomycin is the most expressed antimicrobial peptide in Drosophila melanogaster immune response. A truncated scorpion beta-toxin is capable of binding and inducing conformational alteration of voltage-gated sodium channels. Here, we show that both peptides (i) exhibit anti-fungal activity at micromolar concentrations; (ii) enhance allosterically at nanomolar concentration the activity of LqhalphaIT, a scorpion alpha toxin that modulates the inactivation of the D. melanogaster voltage-gated sodium channel (DmNa(v)1); and (iii) inhibit the facilitating effect of the polyether brevetoxin-2 on DmNa(v)1 activation. Thus, the short CSalphabeta scaffold of drosomycin and the truncated scorpion toxin can maintain more than one bioactivity, and, in light of this new observation, we suggest that the biological role of peptides bearing this scaffold should be carefully examined. As for drosomycin, we discuss the intriguing possibility that it has additional functions in the fly, as implied by its tight interaction with DmNa(v)1.
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