Evidence map›Paper›PMID 19573227›Full record

ArticleHealth and quality of life outcomes2009

Impact of gastroesophageal reflux disease on patients' daily lives: a European observational study in the primary care setting.

Javier P Gisbert, Alun Cooper, Dimitrios Karagiannis, Jan Hatlebakk, Lars Agréus, Helmut Jablonowski, Javier Zapardiel

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Health and quality of life outcomes, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02274636 (Study of a Dietary Supplement for Reflux During Sleep), which is not on this map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02274636 naunknown statusnot on this mapstarted 2014, after this paper: background citation

Study of a Dietary Supplement for Reflux During Sleep

TypeinterventionalSponsorOral Care Research Associates, SeattleRan2014 to 2016Enrolled50ConditionsGERDArmsXylitol
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Guideline
  2. Gastric dysrhythmia in gastroesophageal reflux disease: a systematic review and meta-analysis.Esophagus : official journal of the Japan Esophageal Society · 2021
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  11. Prevalence and factors associated with gastroesophageal reflux disease in southern India: A community-based study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019
    Article
  12. The association between somatic and psychological discomfort and health-related quality of life according to the elderly and non-elderly.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Javier P GisbertDepartment of Gastroenterology, Hospital Universitario de Princesa, Madrid, Spain, and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Spain. gisbert@meditex.es
Alun Cooper
Dimitrios Karagiannis
Jan Hatlebakk
Lars Agréus
Helmut Jablonowski
Javier Zapardiel

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe impact of gastroesophageal reflux disease (GERD) on the daily lives of patients managed in primary care is not well known. We report the burden of GERD in a large population of patients managed in primary care, in terms of symptoms and impact on patients' daily lives.

methodsRANGE (Retrospective ANalysis of GERD) was an observational study that was conducted at 134 primary care sites across six European countries. All adult subjects who had consulted their primary care physician (PCP) during a 4-month identification period were screened retrospectively and those consulting at least once for GERD-related reasons were identified. From this population, a random sample of patients was selected to enter the study and attended a follow-up appointment, during which the Reflux Disease Questionnaire (RDQ), the GERD Impact Scale (GIS) and an extra-esophageal symptoms questionnaire were self-administered. Based on medical records, data were collected on demographics, history of GERD, its diagnostic work-up and therapy.

resultsOver the 4-month identification period, 373,610 subjects consulted their PCP and 12,815 (3.4%) did so for GERD-related reasons. From 2678 patients interviewed (approximately 75% of whom reported taking medication for GERD symptoms), symptom recurrence following a period of remission was the most common reason for consultation (35%). At the follow-up visit, with regard to RDQ items (score range 0-5, where high score = worse status), mean Heartburn dimension scores ranged from 0.8 (Sweden) to 1.2 (UK) and mean Regurgitation dimension scores ranged from 1.0 (Norway) to 1.4 (Germany). Mean overall GIS scores (range 1-4, where low score = worse status) ranged from 3.3 (Germany) to 3.5 (Spain). With regard to extra-esophageal symptoms, sleep disturbance was common in all countries in terms of both frequency and intensity.

conclusionIn this large European observational study, GERD was associated with a substantial impact on the daily lives of affected individuals managed in the primary care setting.

Indexed as

Activities of Daily LivingGastroesophageal RefluxPrimary Health CareQuality of LifeEuropeFemaleHumansMaleMiddle AgedObservationRetrospective Studies

Identifiers

PMID19573227
PMCPMC2714504

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.